Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 834662..835341 Replicon chromosome
Accession NZ_CP023029
Organism Acinetobacter baumannii strain 9102

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4SYJ5
Locus tag Aba9102_RS04080 Protein ID WP_002108505.1
Coordinates 835159..835341 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag Aba9102_RS04075 Protein ID WP_000966688.1
Coordinates 834662..835066 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba9102_RS04055 832831..833577 - 747 WP_000599536.1 hypothetical protein -
Aba9102_RS04060 833639..834022 - 384 WP_000725050.1 hypothetical protein -
Aba9102_RS04065 834055..834378 - 324 WP_000523928.1 DUF4236 domain-containing protein -
Aba9102_RS04070 834387..834563 - 177 WP_075149899.1 hypothetical protein -
Aba9102_RS04075 834662..835066 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Aba9102_RS04080 835159..835341 - 183 WP_002108505.1 type II toxin-antitoxin system HicA family toxin Toxin
Aba9102_RS04090 835667..836182 - 516 WP_001185601.1 hypothetical protein -
Aba9102_RS04095 836252..837169 - 918 WP_000094249.1 hypothetical protein -
Aba9102_RS04100 837222..838400 - 1179 WP_000002423.1 hypothetical protein -
Aba9102_RS04105 838400..838753 - 354 WP_000064612.1 hypothetical protein -
Aba9102_RS04110 838850..839371 - 522 WP_000749906.1 SH3 domain-containing protein -
Aba9102_RS04115 839480..839698 - 219 WP_001277696.1 hypothetical protein -
Aba9102_RS04120 839700..840107 - 408 WP_129533653.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6685.80 Da        Isoelectric Point: 10.5523

>T80347 WP_002108505.1 NZ_CP023029:c835341-835159 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTISHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T80347 NZ_CP023029:c835341-835159 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT80347 WP_000966688.1 NZ_CP023029:c835066-834662 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT80347 NZ_CP023029:c835066-834662 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4SYJ5

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References