Detailed information of TA system TA080345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1490969..1491648
• Replicon: chromosome
• Accession: NZ_CP023026
• Organism: Acinetobacter baumannii strain 10042

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba10042_RS07265
• Protein ID: WP_000838146.1
• Coordinates: 1490969..1491151 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba10042_RS07270
• Protein ID: WP_000966688.1
• Coordinates: 1491244..1491648 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba10042_RS07220	1486093..1486497	+	405	WP_000247948.1	hypothetical protein	-
Aba10042_RS07225	1486469..1486837	+	369	WP_002055488.1	hypothetical protein	-
Aba10042_RS07230	1486839..1487237	+	399	WP_001251850.1	hypothetical protein	-
Aba10042_RS07235	1487239..1487457	+	219	WP_001277687.1	hypothetical protein	-
Aba10042_RS07240	1487551..1487904	+	354	WP_000064599.1	hypothetical protein	-
Aba10042_RS07245	1487904..1489088	+	1185	WP_118898345.1	phage tail protein	-
Aba10042_RS07250	1489141..1490058	+	918	WP_000094250.1	hypothetical protein	-
Aba10042_RS07255	1490128..1490643	+	516	WP_001185608.1	hypothetical protein	-
Aba10042_RS07265	1490969..1491151	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba10042_RS07270	1491244..1491648	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba10042_RS07275	1491747..1491923	+	177	WP_014466185.1	hypothetical protein	-
Aba10042_RS07280	1491932..1492255	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
Aba10042_RS07285	1492287..1493081	+	795	WP_000720608.1	hypothetical protein	-
Aba10042_RS07290	1493130..1493369	-	240	WP_000763623.1	Arc family DNA-binding protein	-
Aba10042_RS07295	1493492..1493647	+	156	WP_001103649.1	Arc family DNA-binding protein	-
Aba10042_RS07300	1493644..1494636	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1457193..1514935	57742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80345 WP_000838146.1 NZ_CP023026:1490969-1491151 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80345 NZ_CP023026:1490969-1491151 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80345 WP_000966688.1 NZ_CP023026:1491244-1491648 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80345 NZ_CP023026:1491244-1491648 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6