Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 1822629..1823282 Replicon chromosome
Accession NZ_CP023022
Organism Acinetobacter baumannii strain 10324

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag Aba10324_RS08785 Protein ID WP_000607074.1
Coordinates 1822629..1823018 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag Aba10324_RS08790 Protein ID WP_001288210.1
Coordinates 1823025..1823282 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba10324_RS08770 1817747..1819942 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
Aba10324_RS08775 1820130..1820696 - 567 WP_000651536.1 rhombosortase -
Aba10324_RS08780 1820774..1821859 - 1086 WP_118878147.1 hypothetical protein -
Aba10324_RS08785 1822629..1823018 - 390 WP_000607074.1 membrane protein Toxin
Aba10324_RS08790 1823025..1823282 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
Aba10324_RS08795 1823470..1824642 + 1173 WP_001190545.1 acyl-CoA dehydrogenase family protein -
Aba10324_RS08800 1824692..1826182 - 1491 WP_000415136.1 NAD(P)/FAD-dependent oxidoreductase -
Aba10324_RS08805 1826363..1826740 - 378 WP_118878149.1 50S ribosomal protein L17 -
Aba10324_RS08810 1826759..1827766 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T80343 WP_000607074.1 NZ_CP023022:c1823018-1822629 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T80343 NZ_CP023022:c1823018-1822629 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT80343 WP_001288210.1 NZ_CP023022:c1823282-1823025 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT80343 NZ_CP023022:c1823282-1823025 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References