Detailed information of TA system TA080342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 787645..788324
• Replicon: chromosome
• Accession: NZ_CP023022
• Organism: Acinetobacter baumannii strain 10324

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba10324_RS03795
• Protein ID: WP_000838146.1
• Coordinates: 788142..788324 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba10324_RS03790
• Protein ID: WP_000966688.1
• Coordinates: 787645..788049 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba10324_RS03770	785924..786250	-	327	WP_000721696.1	hypothetical protein	-
Aba10324_RS03775	786322..787005	-	684	WP_000720504.1	hypothetical protein	-
Aba10324_RS03780	787037..787360	-	324	WP_000523929.1	DUF4236 domain-containing protein	-
Aba10324_RS03785	787369..787545	-	177	WP_075149899.1	hypothetical protein	-
Aba10324_RS03790	787645..788049	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba10324_RS03795	788142..788324	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba10324_RS03805	788650..789165	-	516	WP_118878042.1	hypothetical protein	-
Aba10324_RS03810	789235..790152	-	918	WP_118878044.1	hypothetical protein	-
Aba10324_RS03815	790205..791509	-	1305	WP_118878045.1	pyocin knob domain-containing protein	-
Aba10324_RS03820	791509..791862	-	354	WP_118878047.1	hypothetical protein	-
Aba10324_RS03825	791959..792480	-	522	WP_000749906.1	SH3 domain-containing protein	-
Aba10324_RS03830	792589..792807	-	219	WP_001277696.1	hypothetical protein	-
Aba10324_RS03835	792809..793207	-	399	WP_118878049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	762168..816685	54517

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80342 WP_000838146.1 NZ_CP023022:c788324-788142 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80342 NZ_CP023022:c788324-788142 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80342 WP_000966688.1 NZ_CP023022:c788049-787645 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80342 NZ_CP023022:c788049-787645 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6