Detailed information of TA system TA080341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 510600..512236
• Replicon: chromosome
• Accession: NZ_CP023022
• Organism: Acinetobacter baumannii strain 10324

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4NHR9
• Locus tag: Aba10324_RS02455
• Protein ID: WP_000737055.1
• Coordinates: 510905..512236 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: Aba10324_RS02450
• Protein ID: WP_001101310.1
• Coordinates: 510600..510908 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba10324_RS02445	506026..510057	-	4032	Protein_481	helicase C-terminal domain-containing protein	-
Aba10324_RS02450	510600..510908	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
Aba10324_RS02455	510905..512236	-	1332	WP_000737055.1	type II toxin-antitoxin system HipA family toxin	Toxin
Aba10324_RS02460	512532..512972	+	441	WP_000193136.1	HD domain-containing protein	-
Aba10324_RS02465	513007..513651	-	645	WP_000817306.1	hypothetical protein	-
Aba10324_RS02470	513663..514634	-	972	WP_086225860.1	5'/3'-nucleotidase SurE	-
Aba10324_RS02475	514761..515920	-	1160	Protein_487	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51203.28 Da
• Isoelectric Point: 4.8549

>T80341 WP_000737055.1 NZ_CP023022:c512236-510905 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T80341 NZ_CP023022:c512236-510905 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAGGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTGGTGAAATTCCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAATTAGGTTTCAACACAATTGAAACAACCCAAATG
CAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGTGACTTACTC
AATATCATTTTTGGTAATTCAGATAATCATGGTCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCGGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCGACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCCAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT80341 WP_001101310.1 NZ_CP023022:c510908-510600 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT80341 NZ_CP023022:c510908-510600 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTGTCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTGACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTATTTAAGCCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U4NHR9