Detailed information of TA system TA080340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4019592..4020271
• Replicon: chromosome
• Accession: NZ_CP023020
• Organism: Acinetobacter baumannii strain 9201

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba9201_RS20035
• Protein ID: WP_000838146.1
• Coordinates: 4019592..4019774 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba9201_RS20040
• Protein ID: WP_000966688.1
• Coordinates: 4019867..4020271 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba9201_RS19990	4014703..4015110	+	408	WP_000255076.1	hypothetical protein	-
Aba9201_RS19995	4015082..4015450	+	369	WP_025466445.1	hypothetical protein	-
Aba9201_RS20000	4015452..4015850	+	399	WP_025466443.1	hypothetical protein	-
Aba9201_RS20005	4015852..4016070	+	219	WP_001277694.1	hypothetical protein	-
Aba9201_RS20010	4016166..4016519	+	354	WP_031975507.1	hypothetical protein	-
Aba9201_RS20015	4016519..4017667	+	1149	WP_118896122.1	phage tail protein	-
Aba9201_RS20020	4017764..4018681	+	918	WP_000094278.1	hypothetical protein	-
Aba9201_RS20025	4018751..4019266	+	516	WP_114623142.1	hypothetical protein	-
Aba9201_RS20035	4019592..4019774	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba9201_RS20040	4019867..4020271	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba9201_RS20045	4020370..4020546	+	177	WP_075149899.1	hypothetical protein	-
Aba9201_RS20050	4020555..4020878	+	324	WP_000523928.1	DUF4236 domain-containing protein	-
Aba9201_RS20055	4020911..4021294	+	384	WP_000725050.1	hypothetical protein	-
Aba9201_RS20060	4021356..4022102	+	747	WP_000599536.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3987549..4036155	48606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80340 WP_000838146.1 NZ_CP023020:4019592-4019774 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80340 NZ_CP023020:4019592-4019774 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80340 WP_000966688.1 NZ_CP023020:4019867-4020271 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80340 NZ_CP023020:4019867-4020271 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6