Detailed information of TA system TA080338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1539601..1540280
• Replicon: chromosome
• Accession: NZ_CP023020
• Organism: Acinetobacter baumannii strain 9201

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba9201_RS07775
• Protein ID: WP_000838146.1
• Coordinates: 1540098..1540280 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba9201_RS07770
• Protein ID: WP_000966688.1
• Coordinates: 1539601..1540005 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba9201_RS07750	1537880..1538206	-	327	WP_000721696.1	hypothetical protein	-
Aba9201_RS07755	1538278..1538961	-	684	WP_000720504.1	hypothetical protein	-
Aba9201_RS07760	1538994..1539317	-	324	WP_000523928.1	DUF4236 domain-containing protein	-
Aba9201_RS07765	1539326..1539502	-	177	WP_075149899.1	hypothetical protein	-
Aba9201_RS07770	1539601..1540005	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba9201_RS07775	1540098..1540280	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba9201_RS07785	1540606..1541121	-	516	WP_001185602.1	hypothetical protein	-
Aba9201_RS07790	1541191..1542108	-	918	WP_075149897.1	hypothetical protein	-
Aba9201_RS07795	1542205..1543356	-	1152	WP_063558501.1	hypothetical protein	-
Aba9201_RS07800	1543356..1543709	-	354	WP_063558502.1	hypothetical protein	-
Aba9201_RS07805	1543778..1544176	-	399	WP_001251844.1	hypothetical protein	-
Aba9201_RS07810	1544178..1544546	-	369	WP_063558585.1	hypothetical protein	-
Aba9201_RS07815	1544518..1544925	-	408	WP_000255076.1	hypothetical protein	-
Aba9201_RS20780	1544936..1545106	-	171	WP_000220307.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1513515..1568801	55286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80338 WP_000838146.1 NZ_CP023020:c1540280-1540098 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80338 NZ_CP023020:c1540280-1540098 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80338 WP_000966688.1 NZ_CP023020:c1540005-1539601 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80338 NZ_CP023020:c1540005-1539601 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6