80337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4025307..4027023 Replicon chromosome
Accession NZ_CP023019
Organism Shewanella sp. WE21

Toxin (Protein)


Gene name mosT Uniprot ID A0A2R3EY07
Locus tag CKQ84_RS18020 Protein ID WP_028760212.1
Coordinates 4026088..4027023 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2R3EY57
Locus tag CKQ84_RS18015 Protein ID WP_028760213.1
Coordinates 4025307..4026095 (+) Length 263 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ84_RS17980 4021185..4021371 + 187 Protein_3414 IS91 family transposase -
CKQ84_RS17990 4022077..4022649 + 573 WP_028760218.1 hypothetical protein -
CKQ84_RS17995 4022693..4023013 + 321 WP_028760217.1 hypothetical protein -
CKQ84_RS18000 4023121..4023543 + 423 WP_028760216.1 hypothetical protein -
CKQ84_RS18005 4023644..4024084 + 441 WP_028760215.1 hypothetical protein -
CKQ84_RS18010 4024131..4024643 + 513 WP_028760214.1 hypothetical protein -
CKQ84_RS18015 4025307..4026095 + 789 WP_028760213.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
CKQ84_RS18020 4026088..4027023 + 936 WP_028760212.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CKQ84_RS18025 4027474..4027914 + 441 WP_105252264.1 low molecular weight phosphotyrosine protein phosphatase -
CKQ84_RS18030 4027978..4028280 + 303 WP_081729039.1 hypothetical protein -
CKQ84_RS18035 4028580..4029047 + 468 WP_028760209.1 GNAT family N-acetyltransferase -
CKQ84_RS18040 4030039..4031355 + 1317 WP_105252265.1 hypothetical protein -
CKQ84_RS18045 4031375..4031905 + 531 WP_105252266.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-266)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35357.20 Da        Isoelectric Point: 6.7660

>T80337 WP_028760212.1 NZ_CP023019:4026088-4027023 [Shewanella sp. WE21]
MNKSSIYYQQVTLLIRMLPLVAQEKVFALKGGTAINLFVRNFPRLSVDIDLAYLPLEPREQALQSVKEALGRLTAQINLQ
PNLSAVFQDNKYDELRVVVTSDRVTIKIEVSPVARGTLHKAVLMPVVELVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVKMLLAEEGISREILVGFLTYTLSHPRPINEVMSPRWKPLDESFQTEFNGMTTKPIKLDELILTRSEMLIALQH
HFTAKDRDFLLSFKQGQPDWSLFDEPSVAALPAVRWKLLNIQNLAKNKSKHQEQLIKLADVLETWVAGRIL

Download         Length: 936 bp

>T80337 NZ_CP023019:4026088-4027023 [Shewanella sp. WE21]
ATGAATAAGTCATCGATATACTACCAGCAAGTGACGTTGCTTATTCGGATGCTGCCGCTCGTCGCCCAAGAGAAGGTATT
TGCCCTAAAGGGCGGTACGGCTATCAACCTATTTGTGCGCAACTTCCCACGCTTATCGGTCGATATCGATTTGGCTTATC
TTCCTTTGGAGCCAAGGGAACAAGCGCTACAAAGTGTGAAGGAAGCGCTTGGTCGTTTGACTGCGCAGATCAATCTACAA
CCGAACCTTAGTGCAGTATTTCAAGACAATAAATATGATGAGCTCAGGGTTGTCGTGACAAGTGATAGAGTCACAATAAA
AATTGAAGTCTCTCCTGTTGCGAGAGGTACGCTACACAAAGCGGTATTAATGCCAGTCGTTGAGTTAGTTGAAGAAGAAT
TTGGGTATGCAGAGATCCCCGTTGTAAGCCTGCCTGATCTATACGGTGGTAAGTTATGTGCAGCGATGGATAGACAGCAC
CCAAGGGATCTTTTCGATGTGAAAATGCTGCTGGCGGAAGAGGGGATCAGTCGAGAGATTTTGGTCGGCTTTCTCACTTA
TACACTTAGCCATCCAAGGCCTATTAATGAAGTGATGTCTCCACGCTGGAAACCGCTTGATGAAAGCTTTCAAACTGAAT
TCAATGGAATGACGACAAAGCCGATTAAACTCGATGAGCTGATTTTAACTCGCTCAGAAATGCTGATAGCGTTGCAGCAT
CACTTTACTGCAAAAGACAGAGACTTTTTATTATCCTTTAAACAGGGGCAGCCTGATTGGTCATTGTTTGATGAACCGAG
CGTCGCGGCACTACCTGCGGTGAGATGGAAGCTATTGAATATCCAAAACCTAGCGAAAAACAAATCCAAGCATCAAGAAC
AACTAATTAAACTGGCTGATGTATTGGAAACGTGGGTTGCAGGTCGGATACTGTAA

Antitoxin


Download         Length: 263 a.a.        Molecular weight: 29907.05 Da        Isoelectric Point: 9.5343

>AT80337 WP_028760213.1 NZ_CP023019:4025307-4026095 [Shewanella sp. WE21]
MSSKINWLINHTSPGAVVLQSWLTQNEISSSLVRKYVQSGWLYKISAGVYVRPEPTGKLQPHWVEALKAVNEQLKLPVHL
AGVSSLTHQGLSHYLQLSSEQVWVGCQSKQALPKWFRELEEQNWLFYTSSKLTQTLEKDFITIGVNNREVKASCAELAAY
EVVNAIGKHISFEHAAELFQGLVNLSPRKIQSILNRSEAVQANRVFLFLGHYYQHQWSKRLDEQQITLGAGKRQVVAHGR
YDGRYQITVPASFIKTEENRYE

Download         Length: 789 bp

>AT80337 NZ_CP023019:4025307-4026095 [Shewanella sp. WE21]
ATGTCATCAAAAATAAACTGGCTTATTAATCATACGAGTCCTGGTGCGGTAGTGCTTCAGTCGTGGTTAACACAAAATGA
GATCAGCTCATCTTTGGTGAGAAAATATGTGCAGAGTGGTTGGTTGTACAAGATAAGTGCGGGGGTTTACGTTCGTCCTG
AGCCAACAGGCAAGTTACAGCCTCATTGGGTTGAAGCGCTCAAGGCTGTGAATGAGCAGCTAAAGCTTCCTGTTCACCTT
GCGGGAGTCAGTAGCCTAACACATCAAGGGCTTAGTCATTATCTTCAACTAAGCAGCGAGCAAGTTTGGGTTGGCTGTCA
AAGTAAGCAGGCGTTGCCAAAGTGGTTCCGCGAATTGGAGGAGCAAAACTGGCTTTTCTATACCAGTAGCAAGCTGACCC
AAACGTTGGAAAAAGACTTTATTACTATAGGGGTGAACAATAGGGAAGTTAAGGCAAGTTGTGCGGAGCTTGCAGCCTAT
GAGGTCGTCAATGCCATTGGCAAACATATCAGTTTTGAGCATGCCGCGGAGCTGTTTCAAGGGTTAGTGAATCTCAGTCC
ACGTAAAATACAGTCAATACTGAATCGAAGTGAAGCCGTACAAGCTAATCGCGTATTTCTCTTTTTAGGCCACTACTATC
AACACCAGTGGAGCAAAAGGCTAGATGAGCAGCAAATCACGCTTGGTGCGGGAAAGCGTCAGGTGGTGGCTCATGGCCGT
TACGATGGACGCTATCAAATAACAGTGCCAGCATCGTTTATTAAGACAGAAGAAAATCGATATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3EY07

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3EY57

References