Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2642272..2643813 Replicon chromosome
Accession NZ_CP023019
Organism Shewanella sp. WE21

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CKQ84_RS11440 Protein ID WP_105251367.1
Coordinates 2642512..2643813 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CKQ84_RS11435 Protein ID WP_105253052.1
Coordinates 2642272..2642508 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ84_RS11415 2637305..2638294 + 990 WP_006086115.1 LysR family transcriptional regulator -
CKQ84_RS11420 2638296..2639663 - 1368 WP_105251365.1 MATE family efflux transporter -
CKQ84_RS11425 2639888..2640178 + 291 WP_006086113.1 co-chaperone GroES -
CKQ84_RS11430 2640236..2641864 + 1629 WP_105251366.1 chaperonin GroEL -
CKQ84_RS11435 2642272..2642508 + 237 WP_105253052.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
CKQ84_RS11440 2642512..2643813 + 1302 WP_105251367.1 HipA domain-containing protein Toxin
CKQ84_RS11445 2644305..2644574 + 270 WP_105251368.1 hypothetical protein -
CKQ84_RS11455 2645058..2645621 + 564 WP_158683038.1 hypothetical protein -
CKQ84_RS11460 2645726..2646112 + 387 WP_105251371.1 carboxymuconolactone decarboxylase family protein -
CKQ84_RS11465 2646271..2646522 - 252 WP_006083102.1 DUF2999 domain-containing protein -
CKQ84_RS11470 2646850..2648364 + 1515 WP_105251372.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48643.84 Da        Isoelectric Point: 5.3231

>T80334 WP_105251367.1 NZ_CP023019:2642512-2643813 [Shewanella sp. WE21]
MSTSKKLTLEMHLGDLIIGELSFDATTDTFAVHYTEKWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFKDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAATCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTTIARRIPQAIAEVVSMLPALD
ESETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Download         Length: 1302 bp

>T80334 NZ_CP023019:2642512-2643813 [Shewanella sp. WE21]
ATGAGTACTTCTAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATTATCGGGGAATTGTCCTTTGATGCGACGAC
CGACACCTTTGCCGTGCATTACACCGAAAAGTGGCAACAAAGCGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCAGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTCCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCTATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTAGCGGGTGTACAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCGCTTTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
TAATGAATTTATGACTATGCGCCTAGCTAAGGCGATTGGAATGAATGTGGCTAATGTCGATATTGTTCATTTTAAAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGCAACATGCCGTAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTGACCGGTAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGTGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATCGA
TGACGAATTTGATCCAAACAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGGTTTACCAAGAAATCTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGCTGAGGTGGTTTCAATGCTCCCGGCCCTCGAT
GAGAGTGAAACATCATTTGTGGCTCATTATAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8529.87 Da        Isoelectric Point: 6.2232

>AT80334 WP_105253052.1 NZ_CP023019:2642272-2642508 [Shewanella sp. WE21]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSVQTSDTETNGWY

Download         Length: 237 bp

>AT80334 NZ_CP023019:2642272-2642508 [Shewanella sp. WE21]
ATGGCATCACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACCCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGATATCGTTTCGGTTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References