80333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2354516..2356089 Replicon chromosome
Accession NZ_CP023019
Organism Shewanella sp. WE21

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CKQ84_RS10215 Protein ID WP_105251166.1
Coordinates 2354516..2355823 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CKQ84_RS10220 Protein ID WP_105251167.1
Coordinates 2355823..2356089 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ84_RS10200 2350686..2350880 + 195 Protein_1954 DUF4172 domain-containing protein -
CKQ84_RS10205 2351103..2354270 + 3168 WP_105251165.1 DEAD/DEAH box helicase -
CKQ84_RS10210 2354282..2354509 - 228 Protein_1956 LysR family transcriptional regulator -
CKQ84_RS10215 2354516..2355823 - 1308 WP_105251166.1 type II toxin-antitoxin system HipA family toxin Toxin
CKQ84_RS10220 2355823..2356089 - 267 WP_105251167.1 helix-turn-helix domain-containing protein Antitoxin
CKQ84_RS10225 2356383..2357279 - 897 WP_105251168.1 LysR family transcriptional regulator -
CKQ84_RS10230 2357575..2358255 + 681 WP_105251169.1 pyrimidine 5'-nucleotidase -
CKQ84_RS10235 2358393..2359256 - 864 WP_105251170.1 YicC family protein -
CKQ84_RS10245 2359794..2360507 + 714 WP_006079862.1 ribonuclease PH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49295.59 Da        Isoelectric Point: 6.1379

>T80333 WP_105251166.1 NZ_CP023019:c2355823-2354516 [Shewanella sp. WE21]
MAALDVYMNGFLVGTFSKEDTGAHRFQYNSNWLAIPGNRPISLSMPLRQRHYQGNEVYNFFDNLLPDSPEIRQRILARYQ
ASSTQPFDLLTKVGQDSVGALQLVPQGIEPEDIKKIECEPLDDAALVRVLAGYQSKIPLGMLEEYDDFRISVAGAQEKTA
LLKYDGLWCLPHGSTPTSHIIKLPIGQIVTHSHTLDLSDSVENEYLCMSIAREYGLPVPDCEILKVGNIKALAVERFDRR
YAADNSWLMRLPQEDFCQTLNIPSARKYENQDGPGISEIMYVLMGSLAPERDRRIFMKAQVLFWLLAATDGHAKNFSLFI
RPEGKYELTPLYDIISVYPVLDGTGLNIRDAKLAMGLTATKGKKYQIEQIFPRHFLATANRVGFSQQAMNELLEEFVEKT
PMVIQRIQAQLPDDFPPHIQHSILNGLEHRVRRLL

Download         Length: 1308 bp

>T80333 NZ_CP023019:c2355823-2354516 [Shewanella sp. WE21]
ATGGCTGCACTTGACGTTTATATGAATGGCTTTCTAGTCGGTACTTTCTCTAAAGAAGATACAGGCGCCCATCGATTTCA
ATACAATAGCAACTGGCTGGCTATTCCAGGAAATCGCCCCATATCGTTGTCTATGCCTCTACGCCAACGCCATTATCAGG
GCAATGAAGTTTATAACTTCTTTGATAACTTACTGCCTGACTCACCGGAAATTCGCCAGCGTATCCTCGCACGCTATCAA
GCTAGTTCAACCCAACCCTTCGATTTACTGACTAAAGTCGGCCAAGATAGTGTCGGAGCCTTGCAACTGGTACCACAAGG
TATTGAACCCGAAGACATTAAAAAAATTGAATGTGAACCACTGGATGACGCAGCCCTAGTACGGGTCTTAGCAGGTTACC
AATCCAAGATCCCATTAGGCATGCTCGAAGAATATGACGATTTTCGGATCTCAGTTGCTGGAGCACAGGAAAAAACCGCC
CTGCTGAAATATGATGGTCTGTGGTGTTTACCCCATGGTTCAACGCCAACCAGTCACATAATCAAACTCCCTATCGGCCA
GATAGTCACCCATTCCCACACCTTAGATCTATCGGACAGTGTCGAAAACGAGTACCTGTGCATGTCTATTGCTCGAGAAT
ATGGTTTACCAGTTCCCGATTGCGAAATCCTTAAGGTTGGGAATATCAAGGCGCTCGCGGTCGAACGCTTCGATCGCCGC
TACGCAGCGGACAATAGTTGGCTGATGCGCCTACCACAGGAAGATTTTTGCCAAACCCTTAATATCCCCTCAGCGAGGAA
ATACGAGAACCAAGACGGACCAGGCATTAGCGAGATAATGTACGTATTGATGGGATCGCTTGCCCCAGAAAGAGATCGGC
GCATCTTCATGAAAGCACAAGTGTTATTTTGGTTACTGGCGGCGACAGACGGCCACGCTAAAAACTTTTCGCTATTTATC
AGGCCCGAAGGAAAATACGAGCTTACCCCACTCTACGACATCATCTCCGTTTATCCAGTGCTGGATGGTACAGGACTTAA
CATCCGCGATGCGAAACTGGCCATGGGACTGACAGCCACTAAAGGGAAAAAATACCAGATTGAACAAATCTTTCCCCGCC
ATTTTCTCGCTACGGCAAATCGAGTCGGCTTTAGTCAACAAGCCATGAACGAGCTTCTTGAGGAGTTTGTTGAAAAAACG
CCTATGGTTATCCAACGGATACAAGCGCAACTGCCAGATGATTTCCCCCCACATATCCAGCACAGCATCCTGAACGGGTT
AGAGCATAGGGTAAGGCGACTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9917.09 Da        Isoelectric Point: 5.0651

>AT80333 WP_105251167.1 NZ_CP023019:c2356089-2355823 [Shewanella sp. WE21]
MKITTTKQLSAYIQDVRQSQGLSQAKIGEKIGLRQGTISNFEQNPDSTKLDTFFKLLSALELEIELKPRNASDSDTGSVD
NKQWAQEW

Download         Length: 267 bp

>AT80333 NZ_CP023019:c2356089-2355823 [Shewanella sp. WE21]
ATGAAGATCACCACAACCAAACAGCTTAGCGCTTATATACAAGATGTTCGCCAATCACAGGGACTCTCTCAGGCTAAAAT
TGGTGAGAAAATTGGCTTACGCCAAGGCACAATTTCCAACTTCGAACAGAATCCCGACAGCACTAAACTTGATACATTTT
TCAAACTCTTATCAGCCCTCGAACTCGAAATAGAACTCAAACCTCGCAACGCGAGTGACAGTGATACAGGCTCAGTTGAC
AATAAGCAATGGGCTCAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References