Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 273302..273873 Replicon chromosome
Accession NZ_CP023011
Organism Enterococcus hirae strain FDAARGOS_234

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag A6J73_RS01300 Protein ID WP_094940837.1
Coordinates 273532..273873 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag A6J73_RS01295 Protein ID WP_094940838.1
Coordinates 273302..273532 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J73_RS01285 270308..271273 + 966 WP_081127653.1 helix-turn-helix domain-containing protein -
A6J73_RS01290 271454..272833 - 1380 WP_010738534.1 FAD-dependent oxidoreductase -
A6J73_RS01295 273302..273532 + 231 WP_094940838.1 AbrB family transcriptional regulator Antitoxin
A6J73_RS01300 273532..273873 + 342 WP_094940837.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A6J73_RS01305 274037..275203 - 1167 WP_094940836.1 pyridoxal phosphate-dependent aminotransferase -
A6J73_RS01310 275233..276342 - 1110 WP_164445114.1 amidohydrolase -
A6J73_RS01315 276302..277651 - 1350 WP_053765847.1 aspartate kinase -
A6J73_RS01320 277648..278649 - 1002 WP_094940834.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13128.52 Da        Isoelectric Point: 10.1266

>T80331 WP_094940837.1 NZ_CP023011:273532-273873 [Enterococcus hirae]
VPKVRNYIPKKGDIVWIDFDPSTGKGIQKRRLGLFVSCYEFNCTTMFAIIYPITSTIKNLPTRYSLPKDLDTKGQVLISQ
LKSLDFKERKLKKVENLPLQDMAKIDQIIQYIF

Download         Length: 342 bp

>T80331 NZ_CP023011:273532-273873 [Enterococcus hirae]
GTGCCTAAAGTTAGAAATTATATTCCTAAAAAAGGGGATATTGTTTGGATCGATTTTGATCCATCCACAGGCAAAGGAAT
TCAAAAGAGAAGACTAGGATTGTTTGTATCTTGTTATGAATTTAATTGCACAACAATGTTTGCAATAATCTATCCAATTA
CTTCTACTATAAAAAATCTACCGACACGCTATTCGCTTCCCAAAGATTTAGATACAAAGGGACAAGTACTTATTTCTCAA
TTAAAATCACTTGATTTCAAGGAAAGAAAACTCAAAAAGGTCGAAAATTTACCTTTACAAGATATGGCTAAAATTGATCA
GATTATCCAGTATATATTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8442.43 Da        Isoelectric Point: 4.0078

>AT80331 WP_094940838.1 NZ_CP023011:273302-273532 [Enterococcus hirae]
VLIAKSILQGGSVVITLPSDNGKKPSENQEYIVVYSEDGTITLVPKIEDPFSAGQEAEYYEKDEWKDLTPEGREIL

Download         Length: 231 bp

>AT80331 NZ_CP023011:273302-273532 [Enterococcus hirae]
GTGCTCATTGCAAAATCTATATTACAAGGTGGTTCTGTAGTAATTACTCTACCATCTGATAATGGTAAAAAACCTTCAGA
AAATCAAGAATATATTGTTGTCTACTCTGAAGATGGGACAATCACATTAGTTCCTAAAATCGAAGATCCATTTAGTGCTG
GACAAGAAGCTGAGTATTACGAAAAAGATGAATGGAAAGACTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References