Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1231706..1232331 Replicon chromosome
Accession NZ_CP023009
Organism Lonsdalea britannica strain 477

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CKQ53_RS05790 Protein ID WP_094117889.1
Coordinates 1231706..1232113 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CKQ53_RS05795 Protein ID WP_094117888.1
Coordinates 1232110..1232331 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ53_RS05760 1226759..1227736 + 978 WP_094117894.1 SIS domain-containing protein -
CKQ53_RS05765 1227747..1228559 + 813 WP_094117893.1 ribokinase -
CKQ53_RS05770 1228831..1229733 - 903 WP_085650730.1 hypothetical protein -
CKQ53_RS05775 1229797..1230270 - 474 WP_094117892.1 CesT family type III secretion system chaperone -
CKQ53_RS05780 1230343..1230894 - 552 WP_094117891.1 TetR/AcrR family transcriptional regulator -
CKQ53_RS05785 1230936..1231256 - 321 WP_094117890.1 multidrug efflux SMR transporter -
CKQ53_RS05790 1231706..1232113 - 408 WP_094117889.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CKQ53_RS05795 1232110..1232331 - 222 WP_094117888.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKQ53_RS05800 1232668..1233531 - 864 WP_026738473.1 YicC family protein -
CKQ53_RS05805 1233751..1234659 - 909 WP_094117887.1 LysR family transcriptional regulator -
CKQ53_RS05810 1235075..1236037 - 963 WP_094117886.1 isoaspartyl peptidase/L-asparaginase -
CKQ53_RS05815 1236128..1236949 - 822 WP_094117885.1 M55 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15294.33 Da        Isoelectric Point: 6.2177

>T80327 WP_094117889.1 NZ_CP023009:c1232113-1231706 [Lonsdalea britannica]
MIWISAQEVIAFHDRILQRLPGVAGIPDPGRAEALIYRVQNRAHYEDITDIFELAATYWVAIARGHIFNDGNKRTAFFVT
MAFLHRNGIKIRDNDNALENLTVEAATGEKTVIHLAQHLRDLRDNSISTDFPPVD

Download         Length: 408 bp

>T80327 NZ_CP023009:c1232113-1231706 [Lonsdalea britannica]
ATGATATGGATTAGCGCTCAGGAAGTTATCGCTTTTCATGACCGTATATTGCAACGGCTTCCCGGCGTTGCTGGCATTCC
CGATCCCGGCAGAGCCGAAGCACTGATCTATCGGGTACAGAACCGCGCACACTATGAAGATATAACCGATATTTTCGAGC
TCGCAGCCACTTACTGGGTAGCTATCGCTCGGGGGCATATCTTTAATGATGGCAACAAACGCACCGCGTTTTTCGTGACC
ATGGCTTTTCTCCACCGTAATGGCATCAAAATCCGTGATAACGATAATGCGTTGGAAAATTTAACCGTAGAAGCCGCCAC
GGGAGAAAAGACCGTTATTCATTTAGCGCAGCATCTACGGGATTTGAGGGATAATTCCATTTCCACTGATTTTCCCCCCG
TTGATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8139.94 Da        Isoelectric Point: 5.0497

>AT80327 WP_094117888.1 NZ_CP023009:c1232331-1232110 [Lonsdalea britannica]
MRTYTSTQARAHISEVLDAATQGEAVEITRRDGSSAVVISKSEFEAYQNAKLDAEFDEIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT80327 NZ_CP023009:c1232331-1232110 [Lonsdalea britannica]
ATGCGTACTTACACTTCAACTCAGGCTCGTGCCCATATTTCAGAAGTATTGGATGCCGCCACTCAGGGTGAAGCCGTTGA
AATCACCCGTCGCGATGGAAGTTCTGCGGTAGTGATCAGCAAATCTGAATTCGAGGCATACCAAAACGCGAAACTGGATG
CGGAGTTCGATGAGATTATGCAACGTCATGGTCACACGGTAGAGGCGCTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References