Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 1222127..1222661 Replicon chromosome
Accession NZ_CP023005
Organism Bifidobacterium adolescentis strain 6

Toxin (Protein)


Gene name yafQ Uniprot ID A0A1E7Y0R6
Locus tag CKK50_RS05325 Protein ID WP_070122450.1
Coordinates 1222380..1222661 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V8QB77
Locus tag CKK50_RS05320 Protein ID WP_041777340.1
Coordinates 1222127..1222387 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKK50_RS05305 1218153..1219928 + 1776 WP_046999375.1 glycoside hydrolase family 13 protein -
CKK50_RS05310 1219982..1221349 + 1368 WP_117320012.1 ABC transporter substrate-binding protein -
CKK50_RS05315 1221469..1221933 + 465 WP_117320013.1 D-aminoacyl-tRNA deacylase -
CKK50_RS05320 1222127..1222387 + 261 WP_041777340.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CKK50_RS05325 1222380..1222661 + 282 WP_070122450.1 type II toxin-antitoxin system YafQ family toxin Toxin
CKK50_RS05330 1222680..1222877 - 198 WP_117320014.1 hypothetical protein -
CKK50_RS05335 1222981..1225119 - 2139 WP_117320015.1 DUF2075 domain-containing protein -
CKK50_RS05340 1225179..1225502 + 324 WP_045919873.1 nucleotide pyrophosphohydrolase -
CKK50_RS09290 1226569..1226695 - 127 Protein_1012 DUF1788 domain-containing protein -
CKK50_RS05350 1226714..1227391 - 678 WP_117320016.1 DUF1819 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11180.89 Da        Isoelectric Point: 10.1547

>T80326 WP_070122450.1 NZ_CP023005:1222380-1222661 [Bifidobacterium adolescentis]
MLKSVFRTTQFKKDFKALLKKHYNPDKLRQAIDTLMAQDKQLLSTKYRDHQLTGSWRGYREIHIEGDWLVIYRVEKQELQ
LVLTRTGSHDDLF

Download         Length: 282 bp

>T80326 NZ_CP023005:1222380-1222661 [Bifidobacterium adolescentis]
ATGCTTAAGTCGGTTTTTCGCACAACGCAATTCAAAAAGGATTTCAAGGCTCTGCTTAAAAAGCATTACAATCCCGATAA
GCTTAGACAGGCCATCGACACGCTCATGGCCCAGGACAAACAGTTGCTCAGCACAAAATACCGCGACCATCAGCTGACCG
GAAGCTGGAGGGGATACCGCGAAATCCACATCGAGGGTGACTGGCTCGTCATTTACCGTGTGGAGAAGCAGGAGCTGCAA
CTCGTGCTCACACGCACCGGATCGCATGATGATTTGTTCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9656.83 Da        Isoelectric Point: 4.6028

>AT80326 WP_041777340.1 NZ_CP023005:1222127-1222387 [Bifidobacterium adolescentis]
MSDTATISFRTDPAIKREAKELYADMGMDLSTAINIFLRQSIRENGMPFKITRDNPSSIEARRQAETHDGESFTSTDALM
KDLLDA

Download         Length: 261 bp

>AT80326 NZ_CP023005:1222127-1222387 [Bifidobacterium adolescentis]
ATGAGCGACACTGCGACGATCAGTTTCCGCACGGACCCAGCGATCAAGCGAGAGGCAAAGGAACTGTATGCCGATATGGG
CATGGATCTGTCAACGGCAATCAACATCTTTCTGCGCCAATCAATCCGCGAAAACGGCATGCCTTTCAAGATCACCAGGG
ACAATCCGTCCAGCATTGAGGCACGCCGCCAAGCGGAAACCCATGACGGAGAATCCTTCACCAGCACGGATGCGTTGATG
AAGGATCTGTTGGATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7Y0R6

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8QB77

References