Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 107290..107864 Replicon plasmid p11515TR-B
Accession NZ_CP023000
Organism Rhizobium sp. 11515TR strain 10195

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CKA34_RS27300 Protein ID WP_095437813.1
Coordinates 107499..107864 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CKA34_RS27295 Protein ID WP_095437812.1
Coordinates 107290..107505 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKA34_RS27270 102791..103339 - 549 WP_095437807.1 hypothetical protein -
CKA34_RS27275 103506..104147 - 642 WP_095437808.1 hypothetical protein -
CKA34_RS27280 104208..104816 - 609 WP_095437809.1 hypothetical protein -
CKA34_RS27285 104986..105678 - 693 WP_146214418.1 hypothetical protein -
CKA34_RS34090 105827..106489 - 663 WP_158225460.1 helix-turn-helix domain-containing protein -
CKA34_RS34095 106604..106963 + 360 WP_158225461.1 hypothetical protein -
CKA34_RS27295 107290..107505 + 216 WP_095437812.1 ribbon-helix-helix domain-containing protein Antitoxin
CKA34_RS27300 107499..107864 + 366 WP_095437813.1 type II toxin-antitoxin system VapC family toxin Toxin
CKA34_RS27305 107946..109001 - 1056 WP_095437814.1 NAD(P)H-quinone oxidoreductase -
CKA34_RS27310 108910..109422 - 513 WP_095437815.1 hypothetical protein -
CKA34_RS27315 109541..110455 + 915 WP_095437816.1 LysR family transcriptional regulator -
CKA34_RS27320 110475..111254 - 780 WP_095437817.1 SDR family oxidoreductase -
CKA34_RS27325 111288..112082 - 795 WP_095437818.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1497349 1497349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13689.09 Da        Isoelectric Point: 6.4705

>T80321 WP_095437813.1 NZ_CP023000:107499-107864 [Rhizobium sp. 11515TR]
MVKSLFDTNILIDYLNAVPQARDELTRYREKAISIITWMEILVGAKPEVAIGTRAFLADFAVVVVDGAIAERAVSLRQLH
RIKLPDAIIWATANVHSMLLITRNTKDFPLEMPDIRVPYEI

Download         Length: 366 bp

>T80321 NZ_CP023000:107499-107864 [Rhizobium sp. 11515TR]
ATGGTAAAGTCTCTCTTCGATACCAATATCTTGATCGACTATCTTAATGCCGTACCGCAAGCGCGCGACGAACTGACAAG
ATATCGCGAAAAGGCGATTAGCATTATTACCTGGATGGAGATTCTCGTAGGCGCTAAGCCAGAGGTGGCGATCGGAACGC
GTGCATTCTTGGCGGATTTTGCGGTCGTAGTTGTCGACGGCGCTATAGCCGAACGAGCGGTATCTTTAAGACAACTGCAT
CGCATCAAGCTCCCAGATGCTATTATCTGGGCAACGGCCAATGTCCACTCGATGTTGCTGATCACCCGAAACACCAAGGA
TTTCCCACTGGAAATGCCGGACATTCGAGTGCCTTATGAAATCTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8021.04 Da        Isoelectric Point: 5.0490

>AT80321 WP_095437812.1 NZ_CP023000:107290-107505 [Rhizobium sp. 11515TR]
MRTLVDIGDPEVKALDRLAQREKVSRAALIRKAINDFLARNSTESAADAFGLWGDRQIDGLAYQENMRGEW

Download         Length: 216 bp

>AT80321 NZ_CP023000:107290-107505 [Rhizobium sp. 11515TR]
ATGAGAACGTTGGTGGATATCGGCGACCCAGAAGTCAAAGCGTTGGACCGACTGGCACAGAGGGAAAAAGTGTCAAGGGC
GGCCCTGATCCGTAAGGCGATCAATGATTTTCTAGCTAGGAACAGTACGGAAAGCGCAGCGGATGCATTCGGGCTCTGGG
GTGATCGACAGATCGATGGCTTGGCGTATCAGGAAAACATGCGCGGCGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References