80308

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3181045..3181561 Replicon chromosome
Accession NZ_CP022997
Organism Klebsiella pneumoniae strain 721005

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CI946_RS16065 Protein ID WP_002886902.1
Coordinates 3181045..3181329 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CI946_RS16070 Protein ID WP_002886901.1
Coordinates 3181319..3181561 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI946_RS16045 3176529..3176837 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
CI946_RS28345 3176922..3177095 + 174 WP_002886906.1 hypothetical protein -
CI946_RS16050 3177098..3177841 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CI946_RS16055 3178198..3180336 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CI946_RS16060 3180577..3181041 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CI946_RS16065 3181045..3181329 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CI946_RS16070 3181319..3181561 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CI946_RS16075 3181639..3183549 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CI946_RS16080 3183572..3184726 - 1155 WP_002886900.1 lactonase family protein -
CI946_RS16085 3184792..3185532 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T80308 WP_002886902.1 NZ_CP022997:c3181329-3181045 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T80308 NZ_CP022997:c3181329-3181045 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT80308 WP_002886901.1 NZ_CP022997:c3181561-3181319 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT80308 NZ_CP022997:c3181561-3181319 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References