Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1936664..1938448 Replicon chromosome
Accession NZ_CP022990
Organism Paraburkholderia aromaticivorans strain BN5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CJU94_RS28370 Protein ID WP_095421926.1
Coordinates 1937549..1938448 (-) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CJU94_RS28365 Protein ID WP_095421925.1
Coordinates 1936664..1937548 (-) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJU94_RS28345 1931850..1933340 - 1491 WP_095421921.1 aldehyde dehydrogenase -
CJU94_RS28350 1933381..1934211 - 831 WP_095421922.1 aspartate dehydrogenase -
CJU94_RS28355 1934204..1935862 - 1659 WP_095421923.1 thiamine pyrophosphate-binding protein -
CJU94_RS28360 1935855..1936664 - 810 WP_095421924.1 SDR family oxidoreductase -
CJU94_RS28365 1936664..1937548 - 885 WP_095421925.1 IclR family transcriptional regulator Antitoxin
CJU94_RS28370 1937549..1938448 - 900 WP_095421926.1 alpha/beta fold hydrolase Toxin
CJU94_RS28375 1938494..1939021 - 528 WP_095421927.1 cupin domain-containing protein -
CJU94_RS28380 1939048..1939815 - 768 WP_095421928.1 SDR family oxidoreductase -
CJU94_RS28385 1939808..1940899 - 1092 WP_095421929.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CJU94_RS28390 1940949..1941260 - 312 WP_091805466.1 hypothetical protein -
CJU94_RS28395 1941262..1941576 - 315 WP_091805463.1 non-heme iron oxygenase ferredoxin subunit -
CJU94_RS28400 1942018..1943091 + 1074 WP_095421930.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-280)

Antitoxin

Transcription regulator IclR, C-terminal

(148-272)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31533.63 Da        Isoelectric Point: 7.0190

>T80296 WP_095421926.1 NZ_CP022990:c1938448-1937549 [Paraburkholderia aromaticivorans]
MSAVPSPIADSADQHAPLEARLARFPAQQIWLASQRAVSYREADSADSSALPLVLLHGIGSGAASWVQQFETLGATRRVL
AWDAPGYGASTPVAAESPTAADYARVLNEWLDALGIERCVLLGHSLGAIIAGAFAVTHPQRVAGLLLLSPAGGYGAAPAD
VRNTKRDQRLAMLNELGPQGLAEQRSINMLSAHASDEARAWVRWNMSRVIPHGYAQATHLLANADLAGDLARHQGRINVA
VGADDAITTPEACERIALAARTKLQVVPRAGHAGYIEAPAAHTAIIATFCRTSDGQRSQ

Download         Length: 900 bp

>T80296 NZ_CP022990:c1938448-1937549 [Paraburkholderia aromaticivorans]
ATGTCCGCAGTCCCGTCACCGATCGCTGATAGCGCCGACCAGCACGCTCCGCTCGAAGCCCGCCTCGCGCGCTTCCCGGC
GCAGCAGATCTGGCTGGCGTCGCAACGCGCGGTGAGCTACCGCGAAGCGGATAGCGCCGACAGCAGCGCGCTGCCGCTCG
TGCTGCTGCACGGTATCGGTTCGGGCGCGGCGTCGTGGGTGCAGCAGTTCGAAACACTAGGCGCGACGCGCCGCGTGCTG
GCGTGGGACGCGCCGGGTTACGGCGCATCCACGCCGGTCGCGGCCGAATCGCCCACCGCGGCGGATTACGCGCGCGTGCT
GAACGAATGGCTCGACGCCCTCGGCATTGAACGCTGTGTGCTGCTCGGCCATTCGCTCGGCGCGATTATCGCCGGCGCGT
TTGCCGTGACGCATCCGCAGCGTGTGGCCGGCTTGCTGCTGTTGTCGCCGGCCGGCGGTTACGGCGCGGCGCCCGCCGAT
GTCCGCAACACGAAGCGCGACCAGCGTCTTGCGATGCTGAACGAGCTCGGCCCGCAAGGGCTCGCCGAACAACGCAGTAT
CAACATGTTGTCCGCTCACGCAAGCGACGAAGCACGCGCATGGGTGCGCTGGAACATGTCGCGCGTGATCCCGCACGGCT
ACGCGCAGGCCACGCATCTGCTCGCCAACGCCGATCTCGCTGGCGACCTCGCGCGCCACCAGGGCCGCATCAACGTGGCC
GTGGGCGCGGACGACGCCATTACGACGCCAGAAGCCTGCGAGCGCATCGCGCTGGCCGCCCGCACCAAGTTGCAGGTCGT
GCCTCGCGCGGGGCACGCCGGCTATATCGAAGCACCTGCCGCGCATACCGCGATCATCGCCACGTTCTGCCGCACGAGCG
ACGGACAACGGAGCCAATGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32710.17 Da        Isoelectric Point: 5.8060

>AT80296 WP_095421925.1 NZ_CP022990:c1937548-1936664 [Paraburkholderia aromaticivorans]
MTPDTINAERDADEDRNDTTGDTAYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRTETGLTTHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGTRLPAY
ATTHGQVLMGDMTLDELKKLYPEPELERFTKQTPVTVDDLYERVRDDAQRGFAISESSFERGISVVSAPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPDSGPNAGSKYMKALGL

Download         Length: 885 bp

>AT80296 NZ_CP022990:c1937548-1936664 [Paraburkholderia aromaticivorans]
ATGACGCCCGACACCATTAACGCCGAGCGCGACGCGGACGAAGACCGCAACGACACCACCGGCGACACCGCCTACCGGGT
GCCGGGTCTCGAACGCGGTTTGAAGATACTCACGGAGTTCTCGCCACGCGAGCCGGTTCTCGGCGCACCTGAATTATCGA
AGCGCCTGAAGATTCCTCGCACGACGGTGTTTCGTCTGCTGCAAACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCCGAC
AAGGACCGTAACTATCGCCTCGGCGTCGCGGTGTTGCGGCTCGGTTTCGAGTACCTGAGCTCGCTCGAACTGACCGACCT
CGGCTTGCCGATCATCGAGGCGCTGCGCACGGAAACGGGTCTCACCACCCACATCGTGATTCGCGACGGACGCGATGTCG
TGTTCGTCGCCAAGGCCCAAAGCCACACGCCGATTTTCAGTTCGGTGAAGGTCAACGTGGGTACGCGTCTGCCGGCTTAT
GCGACGACGCACGGCCAGGTGCTGATGGGCGATATGACGCTCGACGAGTTGAAGAAGCTCTATCCCGAGCCGGAACTCGA
GCGCTTTACGAAACAGACGCCCGTTACCGTGGACGACCTGTACGAACGGGTTCGCGACGACGCGCAGCGCGGTTTCGCGA
TCAGCGAGTCGTCGTTCGAGCGTGGCATTTCGGTGGTGAGCGCGCCGGTGCGCAATGACACGGGGCGCATCGTCGCCGTC
ATCACGACGACGATTCCGCGCCACGAGATCGACGCGTCGCTGCTCGACAGCGGCCTGATCGACAAGGTCCGCCGCGCGGC
CGACGAACTTTCGCAACGGCTCAACTATCGGCCAGACAGTGGGCCGAATGCGGGCAGCAAATACATGAAGGCATTGGGGC
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References