Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1347933..1348522 Replicon chromosome
Accession NZ_CP022989
Organism Paraburkholderia aromaticivorans strain BN5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CJU94_RS06060 Protein ID WP_095417946.1
Coordinates 1348340..1348522 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CJU94_RS06055 Protein ID WP_095417945.1
Coordinates 1347933..1348343 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJU94_RS06040 1344287..1346227 + 1941 WP_095417943.1 flagellar biosynthesis protein FlhF -
CJU94_RS06045 1346220..1347089 + 870 WP_095417944.1 AAA family ATPase -
CJU94_RS06050 1347118..1347852 + 735 WP_091798030.1 RNA polymerase sigma factor FliA -
CJU94_RS06055 1347933..1348343 - 411 WP_095417945.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CJU94_RS06060 1348340..1348522 - 183 WP_095417946.1 type II toxin-antitoxin system HicA family toxin Toxin
CJU94_RS06065 1348844..1349290 - 447 WP_095417947.1 flagellar protein FlgN -
CJU94_RS06070 1349385..1349738 - 354 WP_095417948.1 flagellar biosynthesis anti-sigma factor FlgM -
CJU94_RS06075 1349940..1351460 - 1521 WP_095417949.1 flagellar basal body P-ring formation protein FlgA -
CJU94_RS06080 1351678..1352172 + 495 WP_095417950.1 flagellar basal body rod protein FlgB -
CJU94_RS06085 1352285..1352710 + 426 WP_095417951.1 flagellar basal body rod protein FlgC -
CJU94_RS06090 1352721..1353443 + 723 WP_095417952.1 flagellar hook assembly protein FlgD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6511.65 Da        Isoelectric Point: 12.5316

>T80293 WP_095417946.1 NZ_CP022989:c1348522-1348340 [Paraburkholderia aromaticivorans]
MTSAEVVKLIQAAGWRLIRISGSHHHFRHAARGGLVTIPHPKQNLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T80293 NZ_CP022989:c1348522-1348340 [Paraburkholderia aromaticivorans]
ATGACAAGTGCCGAGGTCGTCAAATTGATTCAAGCGGCTGGTTGGCGGCTGATCCGCATTTCGGGCAGCCACCATCATTT
CCGTCACGCGGCAAGAGGCGGTCTCGTGACCATCCCGCACCCGAAGCAAAACCTTCCGCCCGGCACATTGAACAGCATCC
TGAAACAGGCGGGTCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14773.79 Da        Isoelectric Point: 4.4128

>AT80293 WP_095417945.1 NZ_CP022989:c1348343-1347933 [Paraburkholderia aromaticivorans]
MKNLIFPIAIESGDADHAFGVVVPDIPGCYAAGDTLEEAYANAKEAIEAHLDVLLDEGLPIPTRLTLPEHQRNPEYTGFA
WGFVATRNIPALKKAVRINISLPEALVQEIDTYAQTRGMSRSAFLALAAEHEMAEA

Download         Length: 411 bp

>AT80293 NZ_CP022989:c1348343-1347933 [Paraburkholderia aromaticivorans]
ATGAAAAATCTGATTTTCCCGATCGCGATTGAATCGGGCGACGCGGATCACGCGTTCGGCGTTGTCGTGCCCGACATTCC
GGGCTGCTACGCGGCAGGCGACACGTTGGAAGAAGCCTATGCGAATGCGAAAGAAGCCATCGAGGCACATCTGGACGTAC
TGCTCGACGAAGGCTTGCCCATTCCCACGCGACTCACGCTCCCCGAGCATCAGCGCAATCCCGAGTACACCGGTTTCGCA
TGGGGATTCGTCGCCACCCGGAATATTCCCGCCTTGAAGAAGGCGGTGCGTATCAATATCTCGCTGCCCGAGGCGCTGGT
GCAGGAGATCGACACTTACGCCCAGACACGCGGCATGTCGCGCTCGGCCTTCCTGGCACTCGCCGCGGAACATGAAATGG
CAGAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References