80286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2680955..2681963 Replicon chromosome
Accession NZ_CP022985
Organism Mariniflexile sp. TRM1-10

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CJ739_RS11355 Protein ID WP_117175369.1
Coordinates 2681400..2681963 (+) Length 188 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CJ739_RS11350 Protein ID WP_117175367.1
Coordinates 2680955..2681410 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ739_RS11325 2675972..2678110 + 2139 WP_117178920.1 carboxy terminal-processing peptidase -
CJ739_RS11330 2678118..2679212 + 1095 WP_117175359.1 ABC transporter permease -
CJ739_RS11335 2679288..2679761 - 474 WP_117175361.1 GNAT family N-acetyltransferase -
CJ739_RS11340 2679925..2680293 - 369 WP_117175363.1 transcriptional regulator -
CJ739_RS11345 2680305..2680601 - 297 WP_117175365.1 type II toxin-antitoxin system HigB family toxin -
CJ739_RS11350 2680955..2681410 + 456 WP_117175367.1 helix-turn-helix domain-containing protein Antitoxin
CJ739_RS11355 2681400..2681963 + 564 WP_117175369.1 PIN domain-containing protein Toxin
CJ739_RS11360 2682119..2682697 - 579 WP_117175371.1 YdeI family protein -
CJ739_RS11365 2682706..2683092 - 387 WP_117175373.1 DoxX family protein -
CJ739_RS11370 2683099..2683563 - 465 WP_117175375.1 SRPBCC domain-containing protein -
CJ739_RS11375 2683606..2683938 - 333 WP_117175377.1 metalloregulator ArsR/SmtB family transcription factor -
CJ739_RS11385 2684211..2684495 - 285 WP_117175381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(80-127)


Sequences

Toxin        


Download         Length: 188 a.a.        Molecular weight: 21601.80 Da        Isoelectric Point: 6.2311

>T80286 WP_117175369.1 NZ_CP022985:2681400-2681963 [Mariniflexile sp. TRM1-10]
MIHSVRFTCVLDTNVIYPIEIRDLLFWFAHYELFTPKWSNHIFDEWEDVMKRKGITKEEIKKRTNIANSVFPDALVVNYK
PLISGLTLPDEKDRHVLAAAIKTNANVIVTNNLKDFPEEYLATFGLVAKSADDFIADIIDLNHDKALEAFRKLVLNRRNP
DLDTYEVLDNLRKNGLVNSANYLHSLL

Download         Length: 564 bp

>T80286 NZ_CP022985:2681400-2681963 [Mariniflexile sp. TRM1-10]
ATGATTCATAGTGTACGTTTTACATGTGTTCTTGATACCAATGTTATTTATCCAATTGAAATAAGAGATTTGCTTTTTTG
GTTTGCTCATTATGAATTATTTACTCCAAAGTGGAGCAATCATATTTTTGATGAATGGGAAGATGTTATGAAACGAAAAG
GTATAACCAAAGAGGAAATTAAAAAAAGGACAAATATTGCAAATTCAGTATTTCCAGATGCATTAGTCGTGAATTATAAA
CCTTTGATTTCGGGATTGACCTTACCTGATGAAAAAGACCGTCATGTGCTTGCAGCAGCAATAAAAACCAATGCAAATGT
AATAGTGACAAATAATTTAAAAGATTTTCCGGAAGAATATTTAGCTACTTTTGGACTTGTCGCAAAATCTGCTGATGATT
TTATCGCTGATATTATAGATTTAAATCATGATAAAGCATTGGAAGCCTTTAGAAAATTAGTTTTAAATAGAAGAAATCCC
GATTTGGATACATATGAAGTATTAGATAATTTAAGAAAGAATGGATTGGTTAATTCAGCTAATTACCTACATTCGCTTCT
TTAG

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17233.08 Da        Isoelectric Point: 6.1225

>AT80286 WP_117175367.1 NZ_CP022985:2680955-2681410 [Mariniflexile sp. TRM1-10]
MEYFNDIKKPSKKEQIAAMKSYNALAATLEELHSENPEIEIEETAEKIRIPLKALKLLAKILEATSQGHSISVVPIATEM
TTQAAAELLGCSRPHFVKLLEEGKIPFTLVGRHRRVKFEDVMDYKKEMKLKQERLLIDMMKSDEELGLYDS

Download         Length: 456 bp

>AT80286 NZ_CP022985:2680955-2681410 [Mariniflexile sp. TRM1-10]
ATGGAGTACTTTAATGACATAAAAAAGCCTTCAAAAAAAGAGCAAATTGCAGCGATGAAATCGTATAATGCGCTTGCGGC
TACTTTGGAAGAATTGCATTCAGAGAATCCAGAAATTGAAATTGAAGAAACTGCTGAAAAAATAAGAATTCCTTTAAAAG
CGCTTAAACTTTTAGCGAAAATATTAGAGGCAACAAGTCAAGGACATTCAATTTCTGTCGTTCCGATTGCTACTGAAATG
ACAACTCAAGCGGCCGCTGAATTATTAGGTTGTTCAAGACCTCATTTTGTTAAGTTGCTTGAGGAAGGGAAAATTCCATT
TACTTTGGTTGGAAGACATCGTAGAGTGAAATTTGAAGATGTTATGGATTATAAGAAAGAAATGAAATTGAAACAAGAAC
GGCTTTTAATAGATATGATGAAGTCTGATGAAGAGTTAGGATTATATGATTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References