Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 22005..22660 Replicon plasmid pQJDsal2
Accession NZ_CP022965
Organism Salmonella enterica subsp. enterica serovar Pullorum strain QJ-2D-Sal

Toxin (Protein)


Gene name vagD Uniprot ID H9AC96
Locus tag CJD41_RS24515 Protein ID WP_001746752.1
Coordinates 22232..22660 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag CJD41_RS24510 Protein ID WP_001261283.1
Coordinates 22005..22235 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJD41_RS24465 17394..17879 - 486 WP_000905606.1 membrane protein -
CJD41_RS24470 17873..18382 - 510 WP_001576634.1 CaiF/GrlA family transcriptional regulator -
CJD41_RS24480 18386..19099 - 714 Protein_20 EAL domain-containing protein -
CJD41_RS24485 19108..19890 - 783 WP_000082169.1 site-specific integrase -
CJD41_RS24490 19925..20446 - 522 WP_000198608.1 hypothetical protein -
CJD41_RS24495 20443..20733 - 291 WP_001266176.1 hypothetical protein -
CJD41_RS24500 20735..21040 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB -
CJD41_RS24505 21042..21260 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA -
CJD41_RS24510 22005..22235 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CJD41_RS24515 22232..22660 + 429 WP_001746752.1 type II toxin-antitoxin system VapC family toxin Toxin
CJD41_RS24530 23230..24078 - 849 WP_000175397.1 SdiA-regulated domain-containing protein -
CJD41_RS25130 24104..24265 - 162 WP_001816720.1 hypothetical protein -
CJD41_RS24535 24526..24738 - 213 WP_000063791.1 hypothetical protein -
CJD41_RS24540 24811..25395 - 585 WP_024138406.1 hypothetical protein -
CJD41_RS24550 25520..26233 - 714 WP_000801114.1 hypothetical protein -
CJD41_RS24560 26495..27259 - 765 WP_001746754.1 minor fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86369 86369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 18346.91 Da        Isoelectric Point: 12.9522

>T80283 WP_001746752.1 NZ_CP022965:22232-22660 [Salmonella enterica subsp. enterica serovar Pullorum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 429 bp

>T80283 NZ_CP022965:22232-22660 [Salmonella enterica subsp. enterica serovar Pullorum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT80283 WP_001261283.1 NZ_CP022965:22005-22235 [Salmonella enterica subsp. enterica serovar Pullorum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT80283 NZ_CP022965:22005-22235 [Salmonella enterica subsp. enterica serovar Pullorum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A764IXM1

Antitoxin

Source ID Structure
AlphaFold DB A0A6X6R7C5

References