Detailed information of TA system TA080281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 31205..31727
• Replicon: plasmid pQJDsal1
• Accession: NZ_CP022964
• Organism: Salmonella enterica subsp. enterica serovar Pullorum strain QJ-2D-Sal

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: CJD41_RS24150
• Protein ID: WP_000220560.1
• Coordinates: 31446..31727 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: CJD41_RS24145
• Protein ID: WP_000121743.1
• Coordinates: 31205..31456 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJD41_RS25245	26677..26862	+	186	Protein_28	YcxB family protein	-
CJD41_RS25250	27040..27273	+	234	WP_024252801.1	YcxB family protein	-
CJD41_RS24125	27325..27750	-	426	WP_000202953.1	hypothetical protein	-
CJD41_RS24130	27818..28264	-	447	WP_001074384.1	hypothetical protein	-
CJD41_RS24135	28268..29110	-	843	WP_000435064.1	replication initiation protein	-
CJD41_RS24140	29131..29970	-	840	WP_001352874.1	replication initiation protein	-
CJD41_RS24145	31205..31456	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
CJD41_RS24150	31446..31727	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CJD41_RS24155	31873..32196	+	324	WP_001181903.1	hypothetical protein	-
CJD41_RS24160	32241..32486	+	246	WP_000356546.1	hypothetical protein	-
CJD41_RS24165	32476..32718	+	243	WP_075330262.1	hypothetical protein	-
CJD41_RS24170	32783..33112	+	330	WP_000866648.1	hypothetical protein	-
CJD41_RS24175	33155..33334	+	180	WP_000439078.1	hypothetical protein	-
CJD41_RS24180	33404..33553	+	150	WP_000003880.1	hypothetical protein	-
CJD41_RS24185	33566..33838	+	273	WP_000160399.1	hypothetical protein	-
CJD41_RS25255	34095..34169	+	75	Protein_43	DNA distortion polypeptide 3	-
CJD41_RS24195	34164..34709	+	546	WP_001426313.1	hypothetical protein	-
CJD41_RS24200	34712..35878	+	1167	WP_000539538.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..67685	67685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T80281 WP_000220560.1 NZ_CP022964:31446-31727 [Salmonella enterica subsp. enterica serovar Pullorum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T80281 NZ_CP022964:31446-31727 [Salmonella enterica subsp. enterica serovar Pullorum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT80281 WP_000121743.1 NZ_CP022964:31205-31456 [Salmonella enterica subsp. enterica serovar Pullorum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT80281 NZ_CP022964:31205-31456 [Salmonella enterica subsp. enterica serovar Pullorum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301