Detailed information of TA system TA080278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2641659..2642320
• Replicon: chromosome
• Accession: NZ_CP022962
• Organism: Bordetella bronchiseptica strain KM22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: CJ015_RS12430
• Protein ID: WP_003812073.1
• Coordinates: 2641895..2642320 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CJ015_RS12425
• Protein ID: WP_003812071.1
• Coordinates: 2641659..2641898 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ015_RS12390	2636694..2637497	-	804	WP_003812055.1	bacteriocin family protein	-
CJ015_RS12395	2637494..2638540	-	1047	WP_003812057.1	Dyp-type peroxidase	-
CJ015_RS12400	2638618..2639178	-	561	WP_033452199.1	DUF488 domain-containing protein	-
CJ015_RS12405	2639175..2639408	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
CJ015_RS12410	2639489..2640001	-	513	WP_003812062.1	redoxin domain-containing protein	-
CJ015_RS12415	2640060..2640605	-	546	WP_033452198.1	peroxidase-related enzyme	-
CJ015_RS12420	2640743..2641585	+	843	WP_003812068.1	AraC family transcriptional regulator	-
CJ015_RS12425	2641659..2641898	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
CJ015_RS12430	2641895..2642320	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
CJ015_RS12435	2642430..2642894	+	465	WP_003812075.1	MarR family transcriptional regulator	-
CJ015_RS12440	2642992..2644497	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
CJ015_RS12445	2644996..2645508	+	513	WP_003812080.1	hypothetical protein	-
CJ015_RS12450	2645529..2646506	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T80278 WP_003812073.1 NZ_CP022962:2641895-2642320 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T80278 NZ_CP022962:2641895-2642320 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCTCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT80278 WP_003812071.1 NZ_CP022962:2641659-2641898 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT80278 NZ_CP022962:2641659-2641898 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5