Detailed information of TA system TA080276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2108768..2109576
• Replicon: chromosome
• Accession: NZ_CP022961
• Organism: Plantactinospora sp. KBS50

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CIK06_RS09375
• Protein ID: WP_095564504.1
• Coordinates: 2109055..2109576 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: CIK06_RS09370
• Protein ID: WP_095567480.1
• Coordinates: 2108768..2109058 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIK06_RS29890	2103928..2104614	-	687	WP_198348162.1	hypothetical protein	-
CIK06_RS09360	2104884..2106608	+	1725	WP_198348299.1	glycoside hydrolase family 15 protein	-
CIK06_RS09365	2107049..2107828	+	780	WP_095564503.1	hypothetical protein	-
CIK06_RS29265	2107843..2108256	+	414	WP_157756679.1	hypothetical protein	-
CIK06_RS09370	2108768..2109058	+	291	WP_095567480.1	DUF1778 domain-containing protein	Antitoxin
CIK06_RS09375	2109055..2109576	+	522	WP_095564504.1	GNAT family N-acetyltransferase	Toxin
CIK06_RS09380	2109745..2110053	+	309	WP_157756680.1	EndoU domain-containing protein	-
CIK06_RS09385	2110120..2110377	+	258	WP_095567686.1	MafI family immunity protein	-
CIK06_RS09390	2110865..2111029	-	165	Protein_1857	GntR family transcriptional regulator	-
CIK06_RS09400	2111604..2111951	+	348	WP_198348163.1	hypothetical protein	-
CIK06_RS09405	2112443..2112742	+	300	WP_051090560.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CIK06_RS09410	2112752..2112982	+	231	WP_095564507.1	hypothetical protein	-
CIK06_RS29270	2113371..2113643	+	273	WP_157756681.1	hypothetical protein	-
CIK06_RS29275	2113648..2114115	+	468	WP_157756682.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-83)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 18529.31 Da
• Isoelectric Point: 9.0795

>T80276 WP_095564504.1 NZ_CP022961:2109055-2109576 [Plantactinospora sp. KBS50]
VSSRFSSVEPLSAMHVVTGFDCGSPAQSVWLAEHALQAHRAGLSRVYVVADADHPDRRVIGYYALAAGSVAPADASPRLR
QGAGRYHQPVVILTRLGVDRSAQGAGLGRALVVDVLRRIAAAAEVIGVRAVLIHCETDAARDFYLRLAKFEPSPTDPMHL
LLLMTDLRRALAG

Nucleotide

• Length: 522 bp

>T80276 NZ_CP022961:2109055-2109576 [Plantactinospora sp. KBS50]
GTGAGTTCGCGTTTCTCGTCGGTCGAGCCGTTGTCGGCCATGCATGTGGTGACCGGCTTCGACTGCGGCTCGCCTGCTCA
GTCGGTCTGGCTGGCCGAGCACGCCCTGCAGGCGCACCGGGCCGGGCTGTCCCGGGTGTACGTCGTCGCTGACGCCGATC
ACCCGGATCGCCGGGTGATCGGCTATTACGCCCTGGCTGCCGGCAGCGTCGCCCCGGCTGACGCCTCCCCACGGCTGCGG
CAGGGTGCCGGCCGCTACCACCAGCCCGTGGTGATCCTGACCCGCCTCGGCGTCGACCGCAGCGCCCAGGGCGCCGGACT
CGGACGTGCCCTGGTGGTTGATGTGCTGCGGCGCATCGCCGCCGCAGCCGAGGTCATCGGTGTCCGCGCGGTGCTCATCC
ACTGCGAGACCGACGCCGCCCGCGACTTCTATCTGCGCCTGGCCAAGTTCGAGCCGAGTCCCACGGATCCGATGCACCTG
CTGCTGTTGATGACGGACCTCCGCCGAGCTCTCGCGGGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10202.50 Da
• Isoelectric Point: 4.6437

>AT80276 WP_095567480.1 NZ_CP022961:2108768-2109058 [Plantactinospora sp. KBS50]
MSAKAERLHLRVDAEQKALLEAASQAAGASVSTFVLKAATDAAADVLADRRAFLLDEAAWRVFDEALDRPAQDVAGLREL
VAGPTVLDRSAGEVQR

Nucleotide

• Length: 291 bp

>AT80276 NZ_CP022961:2108768-2109058 [Plantactinospora sp. KBS50]
ATGAGTGCGAAGGCGGAGCGGCTACACCTACGGGTGGATGCCGAACAGAAGGCGTTGCTGGAGGCGGCCAGCCAGGCCGC
CGGTGCGAGTGTGTCGACGTTCGTACTGAAGGCGGCCACCGACGCGGCGGCTGACGTGCTCGCCGATCGGCGAGCGTTCC
TGCTGGACGAGGCCGCGTGGCGGGTGTTCGACGAGGCGCTGGACCGCCCGGCCCAGGATGTTGCCGGTCTGCGCGAGTTG
GTGGCTGGGCCGACGGTTCTGGACCGCTCGGCGGGCGAGGTGCAGCGGTGA