Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2276926..2277452 | Replicon | chromosome |
| Accession | NZ_CP022959 | ||
| Organism | Escherichia coli ATCC 8739 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CJZ69_RS11290 | Protein ID | WP_000323025.1 |
| Coordinates | 2277165..2277452 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CJZ69_RS11285 | Protein ID | WP_000534858.1 |
| Coordinates | 2276926..2277165 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CJZ69_RS11255 | 2272263..2272619 | + | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
| CJZ69_RS23740 | 2273230..2273517 | + | 288 | Protein_2120 | hypothetical protein | - |
| CJZ69_RS11270 | 2274286..2275599 | + | 1314 | WP_000589006.1 | ISNCY family transposase | - |
| CJZ69_RS11275 | 2276061..2276393 | - | 333 | WP_001301033.1 | protein FlxA | - |
| CJZ69_RS11280 | 2276596..2276901 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| CJZ69_RS11285 | 2276926..2277165 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CJZ69_RS11290 | 2277165..2277452 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CJZ69_RS11295 | 2277524..2277679 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| CJZ69_RS11300 | 2277896..2278147 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| CJZ69_RS11305 | 2278214..2278492 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| CJZ69_RS11310 | 2278494..2279543 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| CJZ69_RS11315 | 2279557..2280309 | + | 753 | WP_001047134.1 | antitermination protein | - |
| CJZ69_RS23535 | 2280587..2280676 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| CJZ69_RS11320 | 2280731..2280943 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| CJZ69_RS11325 | 2281244..2281459 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| CJZ69_RS23845 | 2281823..2281993 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| CJZ69_RS11330 | 2282213..2282428 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2258616..2323874 | 65258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T80264 WP_000323025.1 NZ_CP022959:2277165-2277452 [Escherichia coli ATCC 8739]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T80264 NZ_CP022959:2277165-2277452 [Escherichia coli ATCC 8739]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT80264 WP_000534858.1 NZ_CP022959:2276926-2277165 [Escherichia coli ATCC 8739]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT80264 NZ_CP022959:2276926-2277165 [Escherichia coli ATCC 8739]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|