Detailed information of TA system TA080249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1234979..1235510
• Replicon: chromosome
• Accession: NZ_CP022958
• Organism: Azoarcus sp. DD4

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: CJ010_RS05895
• Protein ID: WP_141017175.1
• Coordinates: 1235217..1235510 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Y6KPG1
• Locus tag: CJ010_RS05890
• Protein ID: WP_065339862.1
• Coordinates: 1234979..1235227 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ010_RS05865	1230613..1230921	+	309	WP_141017171.1	DUF485 domain-containing protein	-
CJ010_RS05870	1230918..1232636	+	1719	WP_141017172.1	cation acetate symporter	-
CJ010_RS05880	1233145..1234584	+	1440	WP_141017173.1	site-specific integrase	-
CJ010_RS05885	1234581..1234991	+	411	WP_141017174.1	hypothetical protein	-
CJ010_RS05890	1234979..1235227	+	249	WP_065339862.1	plasmid stabilization protein	Antitoxin
CJ010_RS05895	1235217..1235510	+	294	WP_141017175.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CJ010_RS05900	1235642..1237144	-	1503	WP_141017176.1	Fic family protein	-
CJ010_RS05905	1237399..1239378	-	1980	WP_141017177.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10975.75 Da
• Isoelectric Point: 10.4457

>T80249 WP_141017175.1 NZ_CP022958:1235217-1235510 [Azoarcus sp. DD4]
MNYELGFIDEVLAEWRTLDGSVRAQFKTLLAERLKKLPVPAAKLGGHPDRYEIALRRGGHRLVYEMRGQQLVVVIAGGKR
DRNAVFKVADGRCPTER

Nucleotide

• Length: 294 bp

>T80249 NZ_CP022958:1235217-1235510 [Azoarcus sp. DD4]
ATGAACTATGAGCTTGGCTTCATCGATGAGGTCCTGGCCGAGTGGAGAACACTCGACGGCAGCGTCCGGGCGCAGTTCAA
GACGCTGCTGGCCGAGCGTCTGAAAAAGCTGCCCGTGCCGGCAGCCAAGCTCGGGGGGCATCCGGACCGCTATGAAATAG
CGCTCCGCAGGGGTGGGCACCGACTGGTCTATGAGATGCGGGGCCAGCAACTGGTTGTGGTCATCGCGGGCGGCAAGCGG
GATCGCAATGCGGTGTTCAAGGTGGCGGATGGACGCTGCCCTACGGAACGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8871.37 Da
• Isoelectric Point: 6.9755

>AT80249 WP_065339862.1 NZ_CP022958:1234979-1235227 [Azoarcus sp. DD4]
MAHLILAETTATVSELKRNPMGTVAAGEGMPVAILNRSAPVFYCVPAKAYVALMDRLKDLELNLLADTRASQRVTRGTLD
EL

Nucleotide

• Length: 249 bp

>AT80249 NZ_CP022958:1234979-1235227 [Azoarcus sp. DD4]
ATGGCACACCTGATTCTGGCGGAAACTACCGCGACCGTTTCCGAACTGAAGCGCAACCCCATGGGTACGGTTGCGGCGGG
GGAGGGCATGCCCGTTGCAATTCTGAATCGCAGCGCGCCTGTGTTCTATTGTGTTCCCGCAAAGGCCTACGTAGCGCTGA
TGGACCGCTTGAAGGACCTGGAGCTCAATCTCCTTGCCGATACGCGTGCCAGCCAGCGCGTTACCCGGGGGACGCTCGAT
GAACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A4Y6KPG1