Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 370922..371569 Replicon chromosome
Accession NZ_CP022958
Organism Azoarcus sp. DD4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CJ010_RS01810 Protein ID WP_141016452.1
Coordinates 370922..371335 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CJ010_RS01815 Protein ID WP_141016453.1
Coordinates 371336..371569 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ010_RS01780 366099..366743 + 645 WP_141016446.1 OmpA family protein -
CJ010_RS01785 366736..367494 + 759 WP_141016447.1 DUF2894 domain-containing protein -
CJ010_RS01790 367642..368331 - 690 WP_141016448.1 hypothetical protein -
CJ010_RS01795 368328..369410 - 1083 WP_141016449.1 hypothetical protein -
CJ010_RS01800 369407..369679 - 273 WP_141016450.1 acyl carrier protein -
CJ010_RS01805 369676..370935 - 1260 WP_141016451.1 ABC transporter permease -
CJ010_RS01810 370922..371335 - 414 WP_141016452.1 PIN domain-containing protein Toxin
CJ010_RS01815 371336..371569 - 234 WP_141016453.1 antitoxin Antitoxin
CJ010_RS01820 371772..372125 - 354 WP_205754874.1 hypothetical protein -
CJ010_RS01825 372288..373337 - 1050 WP_205754958.1 prolyl oligopeptidase family serine peptidase -
CJ010_RS01830 373491..374723 - 1233 WP_141016456.1 MFS transporter -
CJ010_RS01835 374889..375791 + 903 WP_141016457.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15166.40 Da        Isoelectric Point: 7.4012

>T80248 WP_141016452.1 NZ_CP022958:c371335-370922 [Azoarcus sp. DD4]
VLRYLLDTHIVIYVIKRRPLSALRLFNEHAGQMAISSITLAELYHGAEKCSAPSRTLATVEDFCCRLEVLPYGPKAALHY
GNIRAALERRGTTIGVNDLHIAAHARSEGLALVSNNAREFERVEALQLANWALDEAS

Download         Length: 414 bp

>T80248 NZ_CP022958:c371335-370922 [Azoarcus sp. DD4]
GTGCTGCGCTACCTGCTCGACACCCACATCGTCATCTACGTCATCAAGCGCCGGCCGCTGTCCGCGCTGCGCCTCTTCAA
CGAGCACGCCGGCCAGATGGCGATCTCGTCGATCACGCTGGCCGAGCTCTATCACGGCGCTGAAAAATGCAGCGCGCCCT
CGCGCACGCTGGCCACGGTCGAAGACTTCTGCTGCCGCCTGGAGGTGCTGCCCTACGGCCCGAAAGCCGCGCTGCATTAC
GGCAACATCCGCGCCGCGCTGGAGAGGCGCGGCACGACTATCGGCGTGAACGACCTCCATATCGCCGCCCATGCTCGCAG
CGAAGGCCTGGCGCTGGTATCCAACAACGCACGCGAGTTCGAGCGGGTAGAAGCGCTGCAACTGGCGAACTGGGCACTCG
ATGAAGCAAGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8838.95 Da        Isoelectric Point: 5.0479

>AT80248 WP_141016453.1 NZ_CP022958:c371569-371336 [Azoarcus sp. DD4]
MTTTTIFTNNRTQAVRLPAELRLPDSVKHVDIRARGCERIIAPLDHVWDSFFIDGPTVADDFMESRARQDQPEREAL

Download         Length: 234 bp

>AT80248 NZ_CP022958:c371569-371336 [Azoarcus sp. DD4]
ATGACCACGACCACCATCTTCACCAACAACCGCACCCAGGCCGTGCGCCTGCCCGCCGAGCTGCGCCTGCCCGACAGCGT
CAAGCATGTCGACATTCGCGCCCGCGGCTGCGAACGCATCATCGCCCCGCTCGATCACGTGTGGGACAGCTTCTTCATCG
ACGGCCCCACCGTGGCGGACGACTTCATGGAAAGCCGCGCCCGCCAGGACCAGCCCGAGCGCGAGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References