Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2801906..2802399 Replicon chromosome
Accession NZ_CP022930
Organism Enterococcus durans strain BDGP3

Toxin (Protein)


Gene name relE Uniprot ID A0A2A7SNY0
Locus tag CJZ72_RS13255 Protein ID WP_005880058.1
Coordinates 2801906..2802172 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A7SN65
Locus tag CJZ72_RS13260 Protein ID WP_005880060.1
Coordinates 2802169..2802399 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ72_RS13220 2797259..2798431 - 1173 WP_081135511.1 oxygen-independent coproporphyrinogen III oxidase -
CJZ72_RS13230 2798762..2800144 - 1383 WP_081135508.1 tyrosine-type recombinase/integrase -
CJZ72_RS13235 2800317..2800559 - 243 WP_198324539.1 DUF3850 domain-containing protein -
CJZ72_RS13240 2800622..2801170 - 549 WP_095443952.1 hypothetical protein -
CJZ72_RS13250 2801345..2801788 - 444 WP_198324557.1 hypothetical protein -
CJZ72_RS13255 2801906..2802172 - 267 WP_005880058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CJZ72_RS13260 2802169..2802399 - 231 WP_005880060.1 hypothetical protein Antitoxin
CJZ72_RS13265 2802610..2802762 + 153 WP_081135498.1 putative holin-like toxin -
CJZ72_RS13270 2802998..2803216 - 219 WP_081135496.1 hypothetical protein -
CJZ72_RS13275 2803388..2803651 - 264 WP_081135493.1 hypothetical protein -
CJZ72_RS13280 2803753..2804511 - 759 WP_005880068.1 restriction endonuclease -
CJZ72_RS13290 2804845..2805870 - 1026 WP_016176475.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10563.16 Da        Isoelectric Point: 10.0944

>T80246 WP_005880058.1 NZ_CP022930:c2802172-2801906 [Enterococcus durans]
VTYHLEFTPEIQKQLRKMDKYQATLIVRWLYQHIDGVDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRRNVYD

Download         Length: 267 bp

>T80246 NZ_CP022930:c2802172-2801906 [Enterococcus durans]
GTGACCTATCATTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAATATCAAGCTACATTGATTGT
TCGATGGTTGTATCAACATATTGATGGCGTTGATGACCCGAGAAAATTCGGGAAAGGGTTGACAGCCAATCGTTCAGGGC
AATGGCGTTATCGGATTGGCAAATATCGAGTGTTGGTAGAAATAGAAGATAATCAAATGGTTGTCATTGCTATTCAAGTG
GGACACCGAAGAAATGTCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8850.03 Da        Isoelectric Point: 4.2583

>AT80246 WP_005880060.1 NZ_CP022930:c2802399-2802169 [Enterococcus durans]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWIESGKPTVSMEEILNEFGGLK

Download         Length: 231 bp

>AT80246 NZ_CP022930:c2802399-2802169 [Enterococcus durans]
ATGGCTATGATTACGGTACGTGTGAGTGATGCTGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGAATTACTTT
ATCTGAACTATTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGATCGACAAACAGCTGAAATTGCCCATAAAC
ATTGGATAGAAAGTGGGAAGCCAACTGTATCCATGGAAGAAATACTGAATGAATTTGGAGGACTAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7SNY0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7SN65

References