Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1184392..1185002 Replicon chromosome
Accession NZ_CP022930
Organism Enterococcus durans strain BDGP3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CJZ72_RS05770 Protein ID WP_179135125.1
Coordinates 1184392..1184580 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CJZ72_RS05775 Protein ID WP_081133751.1
Coordinates 1184616..1185002 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ72_RS05760 1181295..1183385 + 2091 WP_095443681.1 DNA mismatch repair endonuclease MutL -
CJZ72_RS05765 1183404..1183961 + 558 WP_081133750.1 septum formation inhibitor Maf -
CJZ72_RS05770 1184392..1184580 + 189 WP_179135125.1 type II toxin-antitoxin system HicA family toxin Toxin
CJZ72_RS05775 1184616..1185002 + 387 WP_081133751.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CJZ72_RS05780 1185319..1187304 - 1986 WP_095443682.1 PTS system trehalose-specific EIIBC component -
CJZ72_RS05785 1187541..1188254 + 714 WP_005875275.1 trehalose operon repressor -
CJZ72_RS05790 1188331..1188771 + 441 WP_081133753.1 peptide-methionine (R)-S-oxide reductase MsrB -
CJZ72_RS05795 1189383..1189985 + 603 WP_081133754.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-103)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7020.30 Da        Isoelectric Point: 10.7808

>T80245 WP_179135125.1 NZ_CP022930:1184392-1184580 [Enterococcus durans]
MPMTIREAEKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL

Download         Length: 189 bp

>T80245 NZ_CP022930:1184392-1184580 [Enterococcus durans]
ATGCCCATGACAATTAGAGAGGCAGAAAAATTACTCAAAGAAGCTGGCTTTGTCGAAGTGAAAGGTGGGAAGGGTTCTCA
CAGGAAATTTATCAAAGAGAATTTTCCGCGCCCGGTCATTCTTACCTGTCATTCAAAAGAGTTATCACAACGAGTAGAAA
ATACTGTCCGAAAGGCAGTGGGCTTATAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14289.47 Da        Isoelectric Point: 4.3660

>AT80245 WP_081133751.1 NZ_CP022930:1184616-1185002 [Enterococcus durans]
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI

Download         Length: 387 bp

>AT80245 NZ_CP022930:1184616-1185002 [Enterococcus durans]
ATGAAAAAAGTATATCCAGCTATTTTTGAAAAAGATCCCGTGGGGTATGGTATTTATTTTCCAGATGTGGAAGGTGCAGT
GACTCAAGCTGAAACTATTTTAGAAGGGCTGGAAGTCGCTTCGGATGCTCTTGGCATAATGCTTGGTGATTTGGTAGAGC
GTAATCTTCCTTTACCTGAGCCAAGTACTATGAAGGAAATTTCCTATGATCCTGAGACGGAGTTTGCTACATTAGTGTCA
GTGGAGTTAGATGACTACTTAAAAGATGTAAAACTTGATAAAAAGACGATAAAGATTCCACATTGGCTAAATGTTAGAGC
GACAAATGAAGGCATTAATTTTTCGAAAACGATGACTGAAGCGTTAGCTAAAAAACTGAATATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References