Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 349198..349805 Replicon chromosome
Accession NZ_CP022930
Organism Enterococcus durans strain BDGP3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CJZ72_RS01750 Protein ID WP_081134843.1
Coordinates 349198..349548 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CJZ72_RS01755 Protein ID WP_081134844.1
Coordinates 349542..349805 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ72_RS01735 345513..346763 + 1251 WP_005878267.1 SPFH domain-containing protein -
CJZ72_RS01740 346786..347997 + 1212 WP_095443574.1 ATP-binding protein -
CJZ72_RS01745 347994..348791 + 798 WP_081134841.1 TPM domain-containing protein -
CJZ72_RS01750 349198..349548 - 351 WP_081134843.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CJZ72_RS01755 349542..349805 - 264 WP_081134844.1 PbsX family transcriptional regulator Antitoxin
CJZ72_RS01760 350149..350805 - 657 WP_005878251.1 Crp/Fnr family transcriptional regulator -
CJZ72_RS01765 350998..351276 + 279 WP_081134846.1 hypothetical protein -
CJZ72_RS01770 351295..352482 + 1188 WP_081134847.1 MFS transporter -
CJZ72_RS01775 352820..353146 - 327 WP_016177343.1 MazG-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13240.22 Da        Isoelectric Point: 8.0294

>T80244 WP_081134843.1 NZ_CP022930:c349548-349198 [Enterococcus durans]
MVRNPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSQYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK

Download         Length: 351 bp

>T80244 NZ_CP022930:c349548-349198 [Enterococcus durans]
ATGGTGAGAAACCCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACATGAACAAACAGGAAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCAGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGTTATATGTAAATATTAATTCACAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCACATGATAGTTTGGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTATTTCAAAAAGTAAGTAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10171.55 Da        Isoelectric Point: 4.6865

>AT80244 WP_081134844.1 NZ_CP022930:c349805-349542 [Enterococcus durans]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKITQEEVNGQKRLIIEAANLENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW

Download         Length: 264 bp

>AT80244 NZ_CP022930:c349805-349542 [Enterococcus durans]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGTCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAACACAAGAAGAAGTAAACGGTCAAAAGCGGCTAATCATCGAAGCGGCTAATTTAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGACGAAAGAAACCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References