Detailed information of TA system TA080238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4767721..4768237
• Replicon: chromosome
• Accession: NZ_CP022924
• Organism: Klebsiella pneumoniae strain ST307PT01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: CJ258_RS23620
• Protein ID: WP_004178374.1
• Coordinates: 4767721..4768005 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A919M0P8
• Locus tag: CJ258_RS23625
• Protein ID: WP_032434351.1
• Coordinates: 4767995..4768237 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ258_RS23600	4763204..4763512	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
CJ258_RS29130	4763597..4763770	+	174	WP_032414379.1	hypothetical protein	-
CJ258_RS23605	4763773..4764516	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
CJ258_RS23610	4764873..4767011	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
CJ258_RS23615	4767253..4767717	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CJ258_RS23620	4767721..4768005	-	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CJ258_RS23625	4767995..4768237	-	243	WP_032434351.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CJ258_RS23630	4768315..4770225	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
CJ258_RS23635	4770248..4771402	-	1155	WP_002886900.1	lactonase family protein	-
CJ258_RS23640	4771468..4772208	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T80238 WP_004178374.1 NZ_CP022924:c4768005-4767721 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T80238 NZ_CP022924:c4768005-4767721 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9003.47 Da
• Isoelectric Point: 6.3340

>AT80238 WP_032434351.1 NZ_CP022924:c4768237-4767995 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Nucleotide

• Length: 243 bp

>AT80238 NZ_CP022924:c4768237-4767995 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A6THG1