Detailed information of TA system TA080217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4761578..4762094
• Replicon: chromosome
• Accession: NZ_CP022922
• Organism: Klebsiella pneumoniae strain ST307PT02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: CJ259_RS23600
• Protein ID: WP_004178374.1
• Coordinates: 4761578..4761862 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A919M0P8
• Locus tag: CJ259_RS23605
• Protein ID: WP_032434351.1
• Coordinates: 4761852..4762094 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ259_RS23580	4757061..4757369	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
CJ259_RS28845	4757454..4757627	+	174	WP_032414379.1	hypothetical protein	-
CJ259_RS23585	4757630..4758373	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
CJ259_RS23590	4758730..4760868	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
CJ259_RS23595	4761110..4761574	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CJ259_RS23600	4761578..4761862	-	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CJ259_RS23605	4761852..4762094	-	243	WP_032434351.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CJ259_RS23610	4762172..4764082	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
CJ259_RS23615	4764105..4765259	-	1155	WP_002886900.1	lactonase family protein	-
CJ259_RS23620	4765325..4766065	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T80217 WP_004178374.1 NZ_CP022922:c4761862-4761578 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T80217 NZ_CP022922:c4761862-4761578 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9003.47 Da
• Isoelectric Point: 6.3340

>AT80217 WP_032434351.1 NZ_CP022922:c4762094-4761852 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Nucleotide

• Length: 243 bp

>AT80217 NZ_CP022922:c4762094-4761852 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A6THG1