Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4673646..4674349 Replicon chromosome
Accession NZ_CP022919
Organism Klebsiella pneumoniae strain ST307PT03

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag CJ256_RS23205 Protein ID WP_071994632.1
Coordinates 4673646..4673987 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag CJ256_RS23210 Protein ID WP_032434296.1
Coordinates 4674008..4674349 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ256_RS23195 4669961..4670830 + 870 WP_023317468.1 HNH endonuclease -
CJ256_RS23200 4671421..4673454 + 2034 WP_050598589.1 hypothetical protein -
CJ256_RS23205 4673646..4673987 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
CJ256_RS23210 4674008..4674349 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CJ256_RS23215 4674360..4674902 - 543 WP_032434298.1 DNA repair protein RadC -
CJ256_RS23220 4674915..4675355 - 441 WP_032434300.1 antirestriction protein -
CJ256_RS23225 4675386..4676207 - 822 WP_032434301.1 DUF945 domain-containing protein -
CJ256_RS23230 4676327..4676800 - 474 WP_032434303.1 hypothetical protein -
CJ256_RS23235 4676872..4677324 - 453 WP_032410767.1 hypothetical protein -
CJ256_RS23240 4677360..4678076 - 717 WP_032434305.1 WYL domain-containing protein -
CJ256_RS23245 4678320..4679194 - 875 Protein_4460 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T80195 WP_071994632.1 NZ_CP022919:c4673987-4673646 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T80195 NZ_CP022919:c4673987-4673646 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT80195 WP_032434296.1 NZ_CP022919:c4674349-4674008 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT80195 NZ_CP022919:c4674349-4674008 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References