Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3499995..3500947 Replicon chromosome
Accession NZ_CP022915
Organism Rhodococcus pyridinivorans strain GF3

Toxin (Protein)


Gene name pezT Uniprot ID H0JT30
Locus tag CJU69_RS16490 Protein ID WP_006552790.1
Coordinates 3500378..3500947 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID H0JT29
Locus tag CJU69_RS16485 Protein ID WP_006552789.1
Coordinates 3499995..3500381 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJU69_RS16460 3495706..3496638 + 933 WP_094980435.1 TAXI family TRAP transporter solute-binding subunit -
CJU69_RS16465 3496963..3497172 + 210 WP_094980436.1 hypothetical protein -
CJU69_RS16470 3497766..3498266 + 501 WP_147430314.1 hypothetical protein -
CJU69_RS16475 3498283..3498648 - 366 WP_094980438.1 HNH endonuclease -
CJU69_RS16480 3498718..3499788 - 1071 WP_197481790.1 class I SAM-dependent methyltransferase -
CJU69_RS16485 3499995..3500381 + 387 WP_006552789.1 hypothetical protein Antitoxin
CJU69_RS16490 3500378..3500947 + 570 WP_006552790.1 zeta toxin family protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-79)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20552.71 Da        Isoelectric Point: 10.6895

>T80158 WP_006552790.1 NZ_CP022915:3500378-3500947 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T80158 NZ_CP022915:3500378-3500947 [Rhodococcus pyridinivorans]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGACCGAAGCGATCGGCCGCGCCGATCAAGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14024.46 Da        Isoelectric Point: 4.5925

>AT80158 WP_006552789.1 NZ_CP022915:3499995-3500381 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRQVLDDA

Download         Length: 387 bp

>AT80158 NZ_CP022915:3499995-3500381 [Rhodococcus pyridinivorans]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAGTACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCAGGTGCTCGACGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7RLW6

Antitoxin

Source ID Structure
AlphaFold DB H0JT29

References