Detailed information of TA system TA080157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 929509..930008
• Replicon: chromosome
• Accession: NZ_CP022915
• Organism: Rhodococcus pyridinivorans strain GF3

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CJU69_RS04465
• Protein ID: WP_019290516.1
• Coordinates: 929754..930008 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1B2UAS3
• Locus tag: CJU69_RS04460
• Protein ID: WP_033098482.1
• Coordinates: 929509..929757 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJU69_RS04445	926590..927822	-	1233	WP_019290511.1	alpha/beta fold hydrolase	-
CJU69_RS04450	927883..928677	-	795	WP_019290512.1	LLM class F420-dependent oxidoreductase	-
CJU69_RS04455	929144..929473	-	330	WP_094979683.1	hypothetical protein	-
CJU69_RS04460	929509..929757	+	249	WP_033098482.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CJU69_RS04465	929754..930008	+	255	WP_019290516.1	Txe/YoeB family addiction module toxin	Toxin
CJU69_RS25250	930109..930630	-	522	WP_183079175.1	hypothetical protein	-
CJU69_RS04475	930787..931743	+	957	WP_019290518.1	Lsr2 family protein	-
CJU69_RS04480	932057..932299	+	243	WP_082331778.1	transposase	-
CJU69_RS25255	932306..932518	+	213	WP_052040167.1	hypothetical protein	-
CJU69_RS04490	932675..933301	-	627	WP_006550849.1	TetR family transcriptional regulator	-
CJU69_RS04495	933404..934573	+	1170	WP_006550848.1	acyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10078.37 Da
• Isoelectric Point: 6.7171

>T80157 WP_019290516.1 NZ_CP022915:929754-930008 [Rhodococcus pyridinivorans]
VNITFTDEAWDDYQFWISTDRKQLERVNELIRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Nucleotide

• Length: 255 bp

>T80157 NZ_CP022915:929754-930008 [Rhodococcus pyridinivorans]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAGCAGCTCGAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9278.54 Da
• Isoelectric Point: 6.4662

>AT80157 WP_033098482.1 NZ_CP022915:929509-929757 [Rhodococcus pyridinivorans]
MAAITATEARRNFFPLVEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEHTEREL
IE

Nucleotide

• Length: 249 bp

>AT80157 NZ_CP022915:929509-929757 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAGAAACTTCTTTCCGCTGGTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAACACACCGAAAGGGAACTC
ATCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B2UAS3