Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 123345..124180 Replicon chromosome
Accession NZ_CP022912
Organism Escherichia coli O6:H16 strain 2011EL-1370-2

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CJZ79_RS00645 Protein ID WP_000854743.1
Coordinates 123345..123722 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CJZ79_RS00650 Protein ID WP_001285298.1
Coordinates 123812..124180 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ79_RS00610 118702..119625 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
CJZ79_RS00615 119736..120920 - 1185 WP_001172882.1 sugar efflux transporter -
CJZ79_RS00630 121716..122554 - 839 Protein_113 DUF4942 domain-containing protein -
CJZ79_RS00635 122651..122848 - 198 WP_000839275.1 DUF957 domain-containing protein -
CJZ79_RS00640 122860..123348 - 489 WP_000761693.1 hypothetical protein -
CJZ79_RS00645 123345..123722 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
CJZ79_RS00650 123812..124180 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CJZ79_RS00655 124230..124874 - 645 WP_000086754.1 hypothetical protein -
CJZ79_RS00660 124893..125114 - 222 WP_000692295.1 DUF987 domain-containing protein -
CJZ79_RS00665 125183..125659 - 477 WP_032328266.1 RadC family protein -
CJZ79_RS00670 125674..126159 - 486 WP_000206660.1 antirestriction protein -
CJZ79_RS00675 126251..127072 - 822 WP_001706654.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 121950..160088 38138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T80128 WP_000854743.1 NZ_CP022912:c123722-123345 [Escherichia coli O6:H16]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T80128 NZ_CP022912:c123722-123345 [Escherichia coli O6:H16]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT80128 WP_001285298.1 NZ_CP022912:c124180-123812 [Escherichia coli O6:H16]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT80128 NZ_CP022912:c124180-123812 [Escherichia coli O6:H16]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References