Detailed information of TA system TA080111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 833768..834300
• Replicon: chromosome
• Accession: NZ_CP022910
• Organism: Staphylococcus aureus strain 164

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CGP88_RS04230
• Protein ID: WP_001103942.1
• Coordinates: 833980..834300 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CGP88_RS04225
• Protein ID: WP_001058486.1
• Coordinates: 833768..833977 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP88_RS04180	828788..830008	-	1221	WP_000266157.1	site-specific integrase	-
CGP88_RS04185	830097..830825	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CGP88_RS04190	830849..831577	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
CGP88_RS04195	831647..832078	-	432	WP_001228759.1	hypothetical protein	-
CGP88_RS04200	832095..832553	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CGP88_RS04205	832565..832897	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CGP88_RS04210	833090..833329	+	240	WP_112368207.1	helix-turn-helix domain-containing protein	-
CGP88_RS04215	833345..833617	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CGP88_RS04220	833629..833775	+	147	WP_000784875.1	hypothetical protein	-
CGP88_RS04225	833768..833977	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CGP88_RS04230	833980..834300	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CGP88_RS04235	834364..835233	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CGP88_RS04240	835250..836707	+	1458	WP_000390455.1	virulence-associated E family protein	-
CGP88_RS04245	837008..837370	+	363	WP_001039168.1	hypothetical protein	-
CGP88_RS04250	837372..837656	+	285	WP_000998181.1	hypothetical protein	-
CGP88_RS04255	837653..838294	+	642	WP_001019764.1	hypothetical protein	-
CGP88_RS04260	838811..839152	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	823433..844102	20669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T80111 WP_001103942.1 NZ_CP022910:833980-834300 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T80111 NZ_CP022910:833980-834300 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT80111 WP_001058486.1 NZ_CP022910:833768-833977 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT80111 NZ_CP022910:833768-833977 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4