Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 816155..816632 Replicon chromosome
Accession NZ_CP022910
Organism Staphylococcus aureus strain 164

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CGP88_RS04075 Protein ID WP_000052078.1
Coordinates 816155..816343 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP88_RS04080 Protein ID WP_001059690.1
Coordinates 816372..816632 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP88_RS04045 812196..812666 + 471 WP_000824472.1 hypothetical protein -
CGP88_RS04050 813007..813693 + 687 WP_001548082.1 thermonuclease family protein -
CGP88_RS04055 814050..814250 + 201 WP_001059082.1 cold-shock protein -
CGP88_RS04060 814746..814964 - 219 WP_000005886.1 hypothetical protein -
CGP88_RS04065 815026..815310 - 285 WP_001004395.1 hypothetical protein -
CGP88_RS04070 815398..815967 - 570 WP_001106654.1 hypothetical protein -
CGP88_RS04075 816155..816343 - 189 WP_000052078.1 hypothetical protein Toxin
CGP88_RS04080 816372..816632 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP88_RS04085 816973..817176 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP88_RS04090 817173..817409 - 237 WP_000368687.1 hypothetical protein -
CGP88_RS04095 817634..818215 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
CGP88_RS04100 818288..818905 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CGP88_RS04105 819060..819554 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP88_RS04110 819953..820375 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGP88_RS04115 820523..821239 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T80110 WP_000052078.1 NZ_CP022910:c816343-816155 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T80110 NZ_CP022910:c816343-816155 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT80110 WP_001059690.1 NZ_CP022910:c816632-816372 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT80110 NZ_CP022910:c816632-816372 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References