Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1117416..1118213 Replicon chromosome
Accession NZ_CP022908
Organism Staphylococcus aureus strain 545

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag CGQ00_RS05790 Protein ID WP_000525009.1
Coordinates 1117416..1117877 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CGQ00_RS05795 Protein ID WP_001260487.1
Coordinates 1117890..1118213 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ00_RS05755 1112726..1113208 + 483 WP_000401377.1 pantetheine-phosphate adenylyltransferase -
CGQ00_RS05760 1113270..1114409 - 1140 WP_000843611.1 nucleotidyltransferase -
CGQ00_RS05765 1114536..1115093 + 558 WP_000872158.1 DUF177 domain-containing protein -
CGQ00_RS05775 1115173..1115346 + 174 WP_000290472.1 50S ribosomal protein L32 -
CGQ00_RS05780 1115463..1116848 - 1386 WP_112367585.1 recombinase family protein -
CGQ00_RS05790 1117416..1117877 - 462 WP_000525009.1 hypothetical protein Toxin
CGQ00_RS05795 1117890..1118213 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CGQ00_RS05800 1118377..1118625 + 249 WP_000272859.1 helix-turn-helix domain-containing protein -
CGQ00_RS05805 1118638..1119081 + 444 WP_023487065.1 hypothetical protein -
CGQ00_RS05810 1119096..1119275 + 180 WP_033861758.1 hypothetical protein -
CGQ00_RS05815 1119376..1119858 - 483 WP_000394410.1 hypothetical protein -
CGQ00_RS05820 1120304..1120489 + 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
CGQ00_RS05825 1120491..1121240 + 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
CGQ00_RS15815 1121256..1121432 + 177 WP_000993178.1 hypothetical protein -
CGQ00_RS05830 1121407..1121637 - 231 WP_000395457.1 hypothetical protein -
CGQ00_RS05835 1121817..1121978 + 162 WP_031929005.1 DUF1270 family protein -
CGQ00_RS05840 1122073..1122333 + 261 WP_115284601.1 DUF1108 family protein -
CGQ00_RS05845 1122343..1122564 + 222 WP_000815403.1 DUF2483 family protein -
CGQ00_RS05850 1122557..1123180 + 624 WP_000139720.1 DUF1071 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1115463..1159073 43610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T80092 WP_000525009.1 NZ_CP022908:c1117877-1117416 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T80092 NZ_CP022908:c1117877-1117416 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT80092 WP_001260487.1 NZ_CP022908:c1118213-1117890 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT80092 NZ_CP022908:c1118213-1117890 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References