Detailed information of TA system TA080091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875548..876080
• Replicon: chromosome
• Accession: NZ_CP022908
• Organism: Staphylococcus aureus strain 545

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CGQ00_RS04530
• Protein ID: WP_001103942.1
• Coordinates: 875760..876080 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CGQ00_RS04525
• Protein ID: WP_001058486.1
• Coordinates: 875548..875757 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ00_RS04480	870567..871787	-	1221	WP_000266157.1	site-specific integrase	-
CGQ00_RS04485	871876..872604	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CGQ00_RS04490	872628..873357	-	730	Protein_823	staphylococcal enterotoxin type Q	-
CGQ00_RS04495	873427..873858	-	432	WP_001228759.1	hypothetical protein	-
CGQ00_RS04500	873875..874333	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CGQ00_RS04505	874345..874677	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CGQ00_RS04510	874870..875109	+	240	WP_112368207.1	helix-turn-helix domain-containing protein	-
CGQ00_RS04515	875125..875397	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CGQ00_RS04520	875409..875555	+	147	WP_000784875.1	hypothetical protein	-
CGQ00_RS04525	875548..875757	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CGQ00_RS04530	875760..876080	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CGQ00_RS04535	876144..877013	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CGQ00_RS04540	877030..878487	+	1458	WP_000390455.1	virulence-associated E family protein	-
CGQ00_RS04545	878788..879150	+	363	WP_001039168.1	hypothetical protein	-
CGQ00_RS04550	879152..879436	+	285	WP_000998181.1	hypothetical protein	-
CGQ00_RS04555	879433..880074	+	642	WP_001019764.1	hypothetical protein	-
CGQ00_RS04560	880591..880932	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	852618..885882	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T80091 WP_001103942.1 NZ_CP022908:875760-876080 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T80091 NZ_CP022908:875760-876080 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT80091 WP_001058486.1 NZ_CP022908:875548-875757 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT80091 NZ_CP022908:875548-875757 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4