Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 857934..858411 Replicon chromosome
Accession NZ_CP022908
Organism Staphylococcus aureus strain 545

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag CGQ00_RS04375 Protein ID WP_000052077.1
Coordinates 857934..858122 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGQ00_RS04380 Protein ID WP_001059690.1
Coordinates 858151..858411 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ00_RS04345 853975..854445 + 471 WP_000824472.1 hypothetical protein -
CGQ00_RS04350 854786..855472 + 687 WP_001548082.1 thermonuclease family protein -
CGQ00_RS04355 855829..856029 + 201 WP_001059082.1 cold-shock protein -
CGQ00_RS04360 856525..856743 - 219 WP_000005886.1 hypothetical protein -
CGQ00_RS04365 856805..857089 - 285 WP_001004395.1 hypothetical protein -
CGQ00_RS04370 857177..857746 - 570 WP_001106654.1 hypothetical protein -
CGQ00_RS04375 857934..858122 - 189 WP_000052077.1 hypothetical protein Toxin
CGQ00_RS04380 858151..858411 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGQ00_RS04385 858752..858955 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGQ00_RS04390 858952..859188 - 237 WP_000368687.1 hypothetical protein -
CGQ00_RS04395 859413..859994 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGQ00_RS04400 860067..860684 - 618 WP_115276602.1 LysE/ArgO family amino acid transporter -
CGQ00_RS04405 860839..861333 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGQ00_RS04410 861732..862154 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGQ00_RS04415 862302..863018 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 852618..885882 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T80090 WP_000052077.1 NZ_CP022908:c858122-857934 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T80090 NZ_CP022908:c858122-857934 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT80090 WP_001059690.1 NZ_CP022908:c858411-858151 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT80090 NZ_CP022908:c858411-858151 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References