Detailed information of TA system TA080074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875551..876083
• Replicon: chromosome
• Accession: NZ_CP022906
• Organism: Staphylococcus aureus strain 546

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CGP99_RS04525
• Protein ID: WP_001103942.1
• Coordinates: 875763..876083 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CGP99_RS04520
• Protein ID: WP_001058486.1
• Coordinates: 875551..875760 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP99_RS04475	870570..871790	-	1221	WP_000266157.1	site-specific integrase	-
CGP99_RS04480	871879..872607	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CGP99_RS04485	872631..873360	-	730	Protein_824	staphylococcal enterotoxin type Q	-
CGP99_RS04490	873430..873861	-	432	WP_001228759.1	hypothetical protein	-
CGP99_RS04495	873878..874336	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CGP99_RS04500	874348..874680	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CGP99_RS04505	874873..875112	+	240	WP_112368207.1	helix-turn-helix domain-containing protein	-
CGP99_RS04510	875128..875400	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CGP99_RS04515	875412..875558	+	147	WP_000784875.1	hypothetical protein	-
CGP99_RS04520	875551..875760	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CGP99_RS04525	875763..876083	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CGP99_RS04530	876147..877016	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CGP99_RS04535	877033..878490	+	1458	WP_000390455.1	virulence-associated E family protein	-
CGP99_RS04540	878791..879153	+	363	WP_001039168.1	hypothetical protein	-
CGP99_RS04545	879155..879439	+	285	WP_000998181.1	hypothetical protein	-
CGP99_RS04550	879436..880077	+	642	WP_001019764.1	hypothetical protein	-
CGP99_RS04555	880594..880935	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	852621..885885	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T80074 WP_001103942.1 NZ_CP022906:875763-876083 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T80074 NZ_CP022906:875763-876083 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT80074 WP_001058486.1 NZ_CP022906:875551-875760 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT80074 NZ_CP022906:875551-875760 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4