Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
Location | 1979694..1980494 | Replicon | chromosome |
Accession | NZ_CP022905 | ||
Organism | Staphylococcus aureus strain 628 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A380E6V7 |
Locus tag | CGQ03_RS10365 | Protein ID | WP_000525007.1 |
Coordinates | 1980030..1980494 (+) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A0C2LD36 |
Locus tag | CGQ03_RS10360 | Protein ID | WP_001260487.1 |
Coordinates | 1979694..1980017 (+) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CGQ03_RS10300 | 1974726..1975151 | - | 426 | WP_000934384.1 | single-stranded DNA-binding protein | - |
CGQ03_RS10305 | 1975151..1975774 | - | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
CGQ03_RS10310 | 1975767..1975988 | - | 222 | WP_000815403.1 | DUF2483 family protein | - |
CGQ03_RS10315 | 1975998..1976258 | - | 261 | WP_000291076.1 | DUF1108 family protein | - |
CGQ03_RS10320 | 1976352..1976513 | - | 162 | WP_000066026.1 | DUF1270 family protein | - |
CGQ03_RS15395 | 1976506..1976643 | - | 138 | WP_000230552.1 | hypothetical protein | - |
CGQ03_RS10325 | 1976693..1976923 | + | 231 | WP_000395455.1 | hypothetical protein | - |
CGQ03_RS10330 | 1977090..1977842 | - | 753 | WP_023487064.1 | phage antirepressor KilAC domain-containing protein | - |
CGQ03_RS10335 | 1977844..1978029 | - | 186 | WP_000933363.1 | helix-turn-helix domain-containing protein | - |
CGQ03_RS10340 | 1978469..1978678 | + | 210 | WP_000642492.1 | hypothetical protein | - |
CGQ03_RS10345 | 1978668..1978811 | - | 144 | WP_000939498.1 | hypothetical protein | - |
CGQ03_RS10350 | 1978826..1979269 | - | 444 | WP_023487065.1 | hypothetical protein | - |
CGQ03_RS10355 | 1979282..1979530 | - | 249 | WP_000272859.1 | helix-turn-helix domain-containing protein | - |
CGQ03_RS10360 | 1979694..1980017 | + | 324 | WP_001260487.1 | helix-turn-helix domain-containing protein | Antitoxin |
CGQ03_RS10365 | 1980030..1980494 | + | 465 | WP_000525007.1 | hypothetical protein | Toxin |
CGQ03_RS10370 | 1980526..1981206 | + | 681 | WP_000392109.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
CGQ03_RS10375 | 1981413..1982798 | + | 1386 | WP_000861313.1 | recombinase family protein | - |
CGQ03_RS10380 | 1982915..1983088 | - | 174 | WP_000290472.1 | 50S ribosomal protein L32 | - |
CGQ03_RS10390 | 1983168..1983725 | - | 558 | WP_000872158.1 | DUF177 domain-containing protein | - |
CGQ03_RS10395 | 1983852..1984991 | + | 1140 | WP_000843611.1 | nucleotidyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1939824..1987960 | 48136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18100.42 Da Isoelectric Point: 4.7904
>T80065 WP_000525007.1 NZ_CP022905:1980030-1980494 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID
Download Length: 465 bp
>T80065 NZ_CP022905:1980030-1980494 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT80065 WP_001260487.1 NZ_CP022905:1979694-1980017 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT80065 NZ_CP022905:1979694-1980017 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A380E6V7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C2LD36 |