Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 871974..872774 Replicon chromosome
Accession NZ_CP022904
Organism Staphylococcus aureus strain 629

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag CGQ02_RS04540 Protein ID WP_000525007.1
Coordinates 871974..872438 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CGQ02_RS04545 Protein ID WP_001260487.1
Coordinates 872451..872774 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ02_RS04510 867477..868616 - 1140 WP_000843611.1 nucleotidyltransferase -
CGQ02_RS04515 868743..869300 + 558 WP_000872158.1 DUF177 domain-containing protein -
CGQ02_RS04525 869380..869553 + 174 WP_000290472.1 50S ribosomal protein L32 -
CGQ02_RS04530 869670..871055 - 1386 WP_000861313.1 recombinase family protein -
CGQ02_RS04535 871262..871942 - 681 WP_000392109.1 type II toxin-antitoxin system PemK/MazF family toxin -
CGQ02_RS04540 871974..872438 - 465 WP_000525007.1 hypothetical protein Toxin
CGQ02_RS04545 872451..872774 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CGQ02_RS04550 872938..873186 + 249 WP_000272859.1 helix-turn-helix domain-containing protein -
CGQ02_RS04555 873199..873642 + 444 WP_023487065.1 hypothetical protein -
CGQ02_RS04560 873657..873800 + 144 WP_000939498.1 hypothetical protein -
CGQ02_RS04565 873790..873999 - 210 WP_000642492.1 hypothetical protein -
CGQ02_RS04570 874439..874624 + 186 WP_000933363.1 helix-turn-helix domain-containing protein -
CGQ02_RS04575 874626..875378 + 753 WP_023487064.1 phage antirepressor KilAC domain-containing protein -
CGQ02_RS04580 875545..875775 - 231 WP_000395455.1 hypothetical protein -
CGQ02_RS15370 875825..875962 + 138 WP_000230552.1 hypothetical protein -
CGQ02_RS04585 875955..876116 + 162 WP_000066026.1 DUF1270 family protein -
CGQ02_RS04590 876210..876470 + 261 WP_000291076.1 DUF1108 family protein -
CGQ02_RS04595 876480..876701 + 222 WP_000815403.1 DUF2483 family protein -
CGQ02_RS04600 876694..877317 + 624 WP_000139720.1 DUF1071 domain-containing protein -
CGQ02_RS04605 877317..877742 + 426 WP_000934384.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 864508..912644 48136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T80048 WP_000525007.1 NZ_CP022904:c872438-871974 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T80048 NZ_CP022904:c872438-871974 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT80048 WP_001260487.1 NZ_CP022904:c872774-872451 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT80048 NZ_CP022904:c872774-872451 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References