Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1963053..1963530 Replicon chromosome
Accession NZ_CP022903
Organism Staphylococcus aureus strain 187

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGQ01_RS10410 Protein ID WP_000052076.1
Coordinates 1963342..1963530 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGQ01_RS10405 Protein ID WP_001059690.1
Coordinates 1963053..1963313 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ01_RS10370 1958446..1959162 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CGQ01_RS10375 1959310..1959732 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGQ01_RS10380 1960131..1960625 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGQ01_RS10385 1960780..1961397 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CGQ01_RS10390 1961470..1962051 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGQ01_RS10395 1962276..1962512 + 237 WP_000349581.1 hypothetical protein -
CGQ01_RS10400 1962509..1962712 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGQ01_RS10405 1963053..1963313 + 261 WP_001059690.1 hypothetical protein Antitoxin
CGQ01_RS10410 1963342..1963530 + 189 WP_000052076.1 hypothetical protein Toxin
CGQ01_RS10415 1963718..1964287 + 570 WP_001106654.1 hypothetical protein -
CGQ01_RS10420 1964375..1964659 + 285 WP_001004399.1 hypothetical protein -
CGQ01_RS10425 1964721..1964939 + 219 WP_000005886.1 hypothetical protein -
CGQ01_RS10430 1965431..1965631 - 201 WP_001059082.1 cold-shock protein -
CGQ01_RS10435 1965988..1966674 - 687 WP_000141557.1 thermonuclease family protein -
CGQ01_RS10440 1967015..1967536 - 522 WP_000824485.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / clfA / clpP 1952512..2031170 78658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T80038 WP_000052076.1 NZ_CP022903:1963342-1963530 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T80038 NZ_CP022903:1963342-1963530 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT80038 WP_001059690.1 NZ_CP022903:1963053-1963313 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT80038 NZ_CP022903:1963053-1963313 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References