Detailed information of TA system TA080037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1920668..1921197
• Replicon: chromosome
• Accession: NZ_CP022903
• Organism: Staphylococcus aureus strain 187

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CGQ01_RS10145
• Protein ID: WP_000621175.1
• Coordinates: 1920668..1921030 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CGQ01_RS10150
• Protein ID: WP_000948331.1
• Coordinates: 1921027..1921197 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ01_RS10120	1917646..1918416	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
CGQ01_RS10125	1918391..1918870	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
CGQ01_RS10130	1918872..1919198	-	327	WP_001052491.1	anti-sigma factor antagonist	-
CGQ01_RS10135	1919317..1920318	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CGQ01_RS10145	1920668..1921030	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CGQ01_RS10150	1921027..1921197	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CGQ01_RS10155	1921282..1922430	-	1149	WP_001281154.1	alanine racemase	-
CGQ01_RS10160	1922496..1922855	-	360	WP_000581197.1	holo-ACP synthase	-
CGQ01_RS10165	1922859..1923350	-	492	WP_001205912.1	PH domain-containing protein	-
CGQ01_RS10170	1923337..1924920	-	1584	WP_001294626.1	PH domain-containing protein	-
CGQ01_RS10175	1924913..1925392	-	480	WP_001287087.1	hypothetical protein	-
CGQ01_RS10180	1925600..1926160	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T80037 WP_000621175.1 NZ_CP022903:c1921030-1920668 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T80037 NZ_CP022903:c1921030-1920668 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT80037 WP_000948331.1 NZ_CP022903:c1921197-1921027 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT80037 NZ_CP022903:c1921197-1921027 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1