Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 870642..871442 Replicon chromosome
Accession NZ_CP022903
Organism Staphylococcus aureus strain 187

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag CGQ01_RS04530 Protein ID WP_000525007.1
Coordinates 870642..871106 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CGQ01_RS04535 Protein ID WP_001260487.1
Coordinates 871119..871442 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGQ01_RS04500 866145..867284 - 1140 WP_000843611.1 nucleotidyltransferase -
CGQ01_RS04505 867411..867968 + 558 WP_000872158.1 DUF177 domain-containing protein -
CGQ01_RS04515 868048..868221 + 174 WP_000290472.1 50S ribosomal protein L32 -
CGQ01_RS04520 868338..869723 - 1386 WP_000861313.1 recombinase family protein -
CGQ01_RS04525 869930..870610 - 681 WP_000392109.1 type II toxin-antitoxin system PemK/MazF family toxin -
CGQ01_RS04530 870642..871106 - 465 WP_000525007.1 hypothetical protein Toxin
CGQ01_RS04535 871119..871442 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CGQ01_RS04540 871606..871854 + 249 WP_000272859.1 helix-turn-helix domain-containing protein -
CGQ01_RS04545 871867..872310 + 444 WP_023487065.1 hypothetical protein -
CGQ01_RS04550 872325..872468 + 144 WP_000939498.1 hypothetical protein -
CGQ01_RS04555 872458..872667 - 210 WP_000642492.1 hypothetical protein -
CGQ01_RS04560 873107..873292 + 186 WP_000933363.1 helix-turn-helix domain-containing protein -
CGQ01_RS04565 873294..874046 + 753 WP_023487064.1 phage antirepressor KilAC domain-containing protein -
CGQ01_RS04570 874213..874443 - 231 WP_000395455.1 hypothetical protein -
CGQ01_RS04575 874623..874784 + 162 WP_000066026.1 DUF1270 family protein -
CGQ01_RS04580 874878..875138 + 261 WP_000291076.1 DUF1108 family protein -
CGQ01_RS04585 875148..875369 + 222 WP_000815403.1 DUF2483 family protein -
CGQ01_RS04590 875362..875985 + 624 WP_000139720.1 DUF1071 domain-containing protein -
CGQ01_RS04595 875985..876410 + 426 WP_000934384.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 868338..911312 42974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T80030 WP_000525007.1 NZ_CP022903:c871106-870642 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T80030 NZ_CP022903:c871106-870642 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT80030 WP_001260487.1 NZ_CP022903:c871442-871119 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT80030 NZ_CP022903:c871442-871119 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References