Detailed information of TA system TA080005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875547..876079
• Replicon: chromosome
• Accession: NZ_CP022902
• Organism: Staphylococcus aureus strain 165

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CGP98_RS04525
• Protein ID: WP_001103942.1
• Coordinates: 875759..876079 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CGP98_RS04520
• Protein ID: WP_001058486.1
• Coordinates: 875547..875756 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP98_RS04475	870566..871786	-	1221	WP_000266157.1	site-specific integrase	-
CGP98_RS04480	871875..872603	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CGP98_RS04485	872627..873356	-	730	Protein_823	staphylococcal enterotoxin type Q	-
CGP98_RS04490	873426..873857	-	432	WP_001228759.1	hypothetical protein	-
CGP98_RS04495	873874..874332	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CGP98_RS04500	874344..874676	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CGP98_RS04505	874869..875108	+	240	WP_112368207.1	helix-turn-helix domain-containing protein	-
CGP98_RS04510	875124..875396	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CGP98_RS04515	875408..875554	+	147	WP_000784875.1	hypothetical protein	-
CGP98_RS04520	875547..875756	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CGP98_RS04525	875759..876079	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CGP98_RS04530	876143..877012	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CGP98_RS04535	877029..878486	+	1458	WP_000390455.1	virulence-associated E family protein	-
CGP98_RS04540	878787..879149	+	363	WP_001039168.1	hypothetical protein	-
CGP98_RS04545	879151..879435	+	285	WP_000998181.1	hypothetical protein	-
CGP98_RS04550	879432..880073	+	642	WP_001019764.1	hypothetical protein	-
CGP98_RS04555	880590..880931	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	852617..885881	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T80005 WP_001103942.1 NZ_CP022902:875759-876079 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T80005 NZ_CP022902:875759-876079 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT80005 WP_001058486.1 NZ_CP022902:875547-875756 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT80005 NZ_CP022902:875547-875756 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4