80004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 857933..858410 Replicon chromosome
Accession NZ_CP022902
Organism Staphylococcus aureus strain 165

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag CGP98_RS04370 Protein ID WP_000052077.1
Coordinates 857933..858121 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP98_RS04375 Protein ID WP_001059690.1
Coordinates 858150..858410 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP98_RS04340 853974..854444 + 471 WP_000824472.1 hypothetical protein -
CGP98_RS04345 854785..855471 + 687 WP_001548082.1 thermonuclease family protein -
CGP98_RS04350 855828..856028 + 201 WP_001059082.1 cold-shock protein -
CGP98_RS04355 856524..856742 - 219 WP_000005886.1 hypothetical protein -
CGP98_RS04360 856804..857088 - 285 WP_001004395.1 hypothetical protein -
CGP98_RS04365 857176..857745 - 570 WP_001106654.1 hypothetical protein -
CGP98_RS04370 857933..858121 - 189 WP_000052077.1 hypothetical protein Toxin
CGP98_RS04375 858150..858410 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP98_RS04380 858751..858954 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP98_RS04385 858951..859187 - 237 WP_000368687.1 hypothetical protein -
CGP98_RS04390 859412..859993 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CGP98_RS04395 860066..860683 - 618 WP_115276602.1 LysE/ArgO family amino acid transporter -
CGP98_RS04400 860838..861332 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP98_RS04405 861731..862153 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CGP98_RS04410 862301..863017 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 852617..885881 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T80004 WP_000052077.1 NZ_CP022902:c858121-857933 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T80004 NZ_CP022902:c858121-857933 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT80004 WP_001059690.1 NZ_CP022902:c858410-858150 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT80004 NZ_CP022902:c858410-858150 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References