Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 856459..856936 Replicon chromosome
Accession NZ_CP022901
Organism Staphylococcus aureus strain 466

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CGP97_RS04200 Protein ID WP_000052076.1
Coordinates 856459..856647 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CGP97_RS04205 Protein ID WP_001059690.1
Coordinates 856676..856936 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP97_RS04170 852412..852969 + 558 WP_000824491.1 hypothetical protein -
CGP97_RS04175 853310..853996 + 687 WP_001574556.1 thermonuclease family protein -
CGP97_RS04180 854353..854553 + 201 WP_001059082.1 cold-shock protein -
CGP97_RS04185 855050..855268 - 219 WP_000005879.1 hypothetical protein -
CGP97_RS04190 855330..855614 - 285 WP_001004401.1 hypothetical protein -
CGP97_RS04195 855702..856271 - 570 WP_001106663.1 hypothetical protein -
CGP97_RS04200 856459..856647 - 189 WP_000052076.1 hypothetical protein Toxin
CGP97_RS04205 856676..856936 - 261 WP_001059690.1 hypothetical protein Antitoxin
CGP97_RS04210 857277..857480 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CGP97_RS04215 857477..857713 - 237 WP_000368687.1 hypothetical protein -
CGP97_RS04220 857938..858519 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CGP97_RS04225 858592..859209 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
CGP97_RS04230 859365..859859 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CGP97_RS04235 860258..860680 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CGP97_RS04240 860828..861544 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T79988 WP_000052076.1 NZ_CP022901:c856647-856459 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T79988 NZ_CP022901:c856647-856459 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT79988 WP_001059690.1 NZ_CP022901:c856936-856676 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT79988 NZ_CP022901:c856936-856676 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References