Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2159980..2160494 Replicon chromosome
Accession NZ_CP022900
Organism Staphylococcus aureus strain 468

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag CGP96_RS11000 Protein ID WP_000581791.1
Coordinates 2159980..2160189 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag CGP96_RS11005 Protein ID WP_000138934.1
Coordinates 2160201..2160494 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP96_RS10980 2155869..2156939 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
CGP96_RS10985 2157257..2158459 + 1203 WP_001109939.1 rod shape-determining protein RodA -
CGP96_RS10990 2158620..2159303 - 684 Protein_2042 transposase -
CGP96_RS10995 2159715..2159852 - 138 WP_000828354.1 hypothetical protein -
CGP96_RS11000 2159980..2160189 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
CGP96_RS11005 2160201..2160494 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
CGP96_RS11010 2160660..2162144 + 1485 WP_000571560.1 cardiolipin synthase -
CGP96_RS11015 2162172..2162819 + 648 WP_001187612.1 HD domain-containing protein -
CGP96_RS11030 2163432..2164304 - 873 WP_000725802.1 membrane protein insertase YidC -
CGP96_RS11035 2164390..2165031 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T79982 WP_000581791.1 NZ_CP022900:c2160189-2159980 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T79982 NZ_CP022900:c2160189-2159980 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT79982 WP_000138934.1 NZ_CP022900:c2160494-2160201 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT79982 NZ_CP022900:c2160494-2160201 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References