Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1998128..1998916 Replicon chromosome
Accession NZ_CP022900
Organism Staphylococcus aureus strain 468

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag CGP96_RS10130 Protein ID WP_000525012.1
Coordinates 1998455..1998916 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag CGP96_RS10125 Protein ID WP_000333630.1
Coordinates 1998128..1998442 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP96_RS10070 1993364..1993915 - 552 WP_000704705.1 single-stranded DNA-binding protein -
CGP96_RS10075 1993944..1994732 - 789 WP_000134097.1 ATP-binding protein -
CGP96_RS10080 1994725..1994946 - 222 WP_000815402.1 DUF2483 family protein -
CGP96_RS10085 1994956..1995216 - 261 WP_000291089.1 DUF1108 family protein -
CGP96_RS10090 1995312..1995473 - 162 WP_000066011.1 DUF1270 domain-containing protein -
CGP96_RS10095 1995466..1995687 - 222 WP_000594789.1 hypothetical protein -
CGP96_RS10100 1995758..1995988 + 231 WP_000395455.1 hypothetical protein -
CGP96_RS10105 1996164..1996904 - 741 WP_001148585.1 phage antirepressor KilAC domain-containing protein -
CGP96_RS10110 1996964..1997446 + 483 WP_000394410.1 hypothetical protein -
CGP96_RS10115 1997547..1997726 - 180 WP_000438352.1 hypothetical protein -
CGP96_RS10120 1997740..1997976 - 237 WP_001121116.1 helix-turn-helix domain-containing protein -
CGP96_RS10125 1998128..1998442 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
CGP96_RS10130 1998455..1998916 + 462 WP_000525012.1 hypothetical protein Toxin
CGP96_RS10135 1998937..1999428 + 492 WP_001077638.1 hypothetical protein -
CGP96_RS10140 1999554..1999733 - 180 WP_000337827.1 hypothetical protein -
CGP96_RS10145 1999846..2000892 + 1047 WP_001145721.1 site-specific integrase -
CGP96_RS10150 2000937..2002082 + 1146 WP_001245443.1 radical SAM/CxCxxxxC motif protein YfkAB -
CGP96_RS10155 2002342..2002872 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1961522..2002872 41350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-62)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 17963.27 Da        Isoelectric Point: 4.5941

>T79980 WP_000525012.1 NZ_CP022900:1998455-1998916 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDAEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T79980 NZ_CP022900:1998455-1998916 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATGCAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT79980 WP_000333630.1 NZ_CP022900:1998128-1998442 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT79980 NZ_CP022900:1998128-1998442 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGAGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References